{"id":82,"date":"2015-07-06T13:35:40","date_gmt":"2015-07-06T04:35:40","guid":{"rendered":"http:\/\/meti-nano-en.aist-riss.jp\/?page_id=51"},"modified":"2021-10-06T13:18:20","modified_gmt":"2021-10-06T04:18:20","slug":"result07","status":"publish","type":"page","link":"https:\/\/riss.aist.go.jp\/metinanoen\/result\/result07\/","title":{"rendered":"Research and development item: \u2461(d) Development of a method of capturing aerosol particles in liquids"},"content":{"rendered":"<p>Implemented by the National Institute of Advanced Industrial Science and Technology<\/p>\n<p>Final objective: As a method to make nanomaterial suspension for intratracheal administration-testing applicable to any aerosol sample, we establish a technique for preparing nanomaterial suspensions by directly collecting dry-dispersed nanomaterial powder into liquid. Our objective is to minimize physico-chemical dispersion processes during the preparation of nanomaterial liquid suspension. We compile and release a draft which explains standard procedures of this method.<\/p>\n<p>Intratracheal administration-testing uses liquid suspension, and nanomaterial are often physico-chemically dispersed in liquid. On the other hand, inhalation-testing, which is considered as the golden standard method, uses dry-dispersed aerosol sample. Properties related to the hazard posed by nanomaterial powder may differ between these two samples. By directly collecting the dry-dispersed nanomaterial powder into liquid, the nanomaterial suspensions are expected to have similar properties regarding its toxicity to the dry-dispersed nanomaterial for inhalation-testing.<\/p>\n<p><a href=\"\/metinanoen\/wp-content\/uploads\/sites\/17\/2021\/10\/r-07-1.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-434\" src=\"\/metinanoen\/wp-content\/uploads\/sites\/17\/2021\/10\/r-07-1.png\" alt=\"r-07-1\" width=\"1024\" height=\"680\" \/><\/a><\/p>\n<p style=\"text-align: center;\">Figure\u2461(d)-1\u00a0Standpoint of the aerosol-to-liquid collection method in the hazard assessment of nanomaterials<\/p>\n<p>Main results:<br \/>\nWe developed a technique for directly collecting dry-dispersed nanomaterials into liquid. Two essential elements of this aerosol-to-liquid-collection-method are (1) dry-dispersion technique to aerosolize nanomaterial with high temporal stability and (2) a technique to efficiently collect aerosolized nanomaterial-aggregates in liquid.<\/p>\n<p>With respect to (1), we improved a vibrating membrane aerosol generator of NIOSH-type USA and demonstrated that P25 TiO<sub>2<\/sub> could be aerosolized steadily for extended periods at mass concentration of \u226510 mg\/m<sup>3<\/sup> (Figures \u2461(d)-2(a) and \u2461(d)-3(a)).<\/p>\n<p>With respect to (2), we uses a condensation particle trap (CPT). Inside the CPT super-saturated water vapor nucleate and condense to aerosolized nanomaterial aggregates, growing them into droplets whose diameter are approximately 3 \u03bcm. At the exit of CPT, grown droplets were accelerated through nozzles and deposited by inertia onto a liquid surface. (Figure 2(b)). We demonstrated that P25 TiO<sub>2<\/sub> suspension was successfully prepared by this method. By carrying out 5 to 6 hours of aerosol-to-liquid-collection method, it is possible to prepare a liquid suspension of the TiO<sub>2<\/sub> with concentration of 1 mg\/mL and the volume of 5-10 mL (Figure 3(b)).<\/p>\n<p><a href=\"\/metinanoen\/wp-content\/uploads\/sites\/17\/2021\/10\/r-07-2.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-435\" src=\"\/metinanoen\/wp-content\/uploads\/sites\/17\/2021\/10\/r-07-2.png\" alt=\"r-07-2\" width=\"1024\" height=\"450\" \/><\/a><\/p>\n<p style=\"text-align: center;\">Figure\u2461(d)-2 Overview of (a) the nanomaterial powder dry aerosolization system and (b) the condensation particle trap<\/p>\n<p><a href=\"\/metinanoen\/wp-content\/uploads\/sites\/17\/2021\/10\/r-07-3.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-436 size-full\" src=\"\/metinanoen\/wp-content\/uploads\/sites\/17\/2021\/10\/r-07-3.png\" alt=\"r-07-3\" width=\"1024\" height=\"480\" \/><\/a><\/p>\n<p style=\"text-align: center;\">Figure\u2461(d)-3\u00a0(a) Aerosol mass concentration of dry-dispersed P25 TiO<sub>2<\/sub>, and (b) a photograph showing a liquid suspension of P25 TiO<sub>2<\/sub> prepared using the aerosol-to-liquid collection method.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Implemented by the National Institute of Advanced Industrial Science and Technology Final objective: As a meth [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":74,"menu_order":14,"comment_status":"open","ping_status":"open","template":"","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":"","_links_to":"","_links_to_target":""},"tags":[],"class_list":["post-82","page","type-page","status-publish","hentry"],"aioseo_notices":[],"acf":[],"_links":{"self":[{"href":"https:\/\/riss.aist.go.jp\/metinanoen\/wp-json\/wp\/v2\/pages\/82","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/riss.aist.go.jp\/metinanoen\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/riss.aist.go.jp\/metinanoen\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/riss.aist.go.jp\/metinanoen\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/riss.aist.go.jp\/metinanoen\/wp-json\/wp\/v2\/comments?post=82"}],"version-history":[{"count":3,"href":"https:\/\/riss.aist.go.jp\/metinanoen\/wp-json\/wp\/v2\/pages\/82\/revisions"}],"predecessor-version":[{"id":192,"href":"https:\/\/riss.aist.go.jp\/metinanoen\/wp-json\/wp\/v2\/pages\/82\/revisions\/192"}],"up":[{"embeddable":true,"href":"https:\/\/riss.aist.go.jp\/metinanoen\/wp-json\/wp\/v2\/pages\/74"}],"wp:attachment":[{"href":"https:\/\/riss.aist.go.jp\/metinanoen\/wp-json\/wp\/v2\/media?parent=82"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/riss.aist.go.jp\/metinanoen\/wp-json\/wp\/v2\/tags?post=82"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}