{"id":190,"date":"2015-07-03T18:43:46","date_gmt":"2015-07-03T09:43:46","guid":{"rendered":"http:\/\/meti-nano-jp.aist-riss.jp\/?page_id=190"},"modified":"2016-10-20T16:54:29","modified_gmt":"2016-10-20T07:54:29","slug":"publication","status":"publish","type":"page","link":"https:\/\/riss.aist.go.jp\/metinanojp\/publication\/","title":{"rendered":"\u8ad6\u6587\u7b49\u4e00\u89a7"},"content":{"rendered":"<h3>\u2460\u3000\u30ca\u30ce\u6750\u6599\u306e\u540c\u7b49\u6027\u5224\u65ad\u306e\u305f\u3081\u306e\u8a55\u4fa1\u6280\u8853\u306e\u69cb\u7bc9<\/h3>\n<h5 id=\"1a\">\u2460(a) \u6c17\u7ba1\u5185\u6295\u4e0e\u8a66\u9a13\u306b\u3088\u308b\u30ca\u30ce\u6750\u6599\u306e\u76f8\u4e92\u6bd4\u8f03\u306b\u3088\u308b\u540c\u7b49\u6027\u5224\u65ad\u57fa\u6e96\u306e\u69cb\u7bc9<\/h5>\n<p>\u5b9f\u65bd\u6a5f\u95a2\uff1a\u5316\u5b66\u7269\u8cea\u8a55\u4fa1\u7814\u7a76\u6a5f\u69cb<\/p>\n<p>Hashizume N, Oshima Y, Nakai M, Kobayashi T, Sasaki T, Kawaguchi K, Honda K, Gamo M, Yamamoto K, Tsubokura Y, Ajimi S, Inoue Y, Imatanaka N (2016). Categorization of nano-structured titanium dioxide according to physicochemical characteristics and pulmonary toxicity. Toxicology Reports. 3, 490\u2013500.<\/p>\n<p>Tsubokura Y, Oshima Y, Kobayashi T, Kikuchi J, Hashizume N, Nakai M, Ajimi S, Imatanaka N, Furukawa F (2013). Pulmonary toxicity of several nano TiO<sub>2<\/sub> by intratracheal administration in rats. 6th International Symposium on Nanotechnology, Occupational and Environmental Health. P-02-042. (Aichi, October 28-31, 2013)<\/p>\n<h5 id=\"1b\">\u2460(b) \u540c\u7b49\u6027\u8a55\u4fa1\u306e\u305f\u3081\u306e\u8a66\u6599\u8abf\u88fd\u6280\u8853\u3068\u30ad\u30e3\u30e9\u30af\u30bf\u30ea\u30bc\u30fc\u30b7\u30e7\u30f3<\/h5>\n<p>\u5b9f\u65bd\u6a5f\u95a2\uff1a\u7523\u696d\u6280\u8853\u7dcf\u5408\u7814\u7a76\u6240 \u30ca\u30ce\u6750\u6599\u7814\u7a76\u90e8\u9580<\/p>\n<p>&nbsp;<\/p>\n<h3>\u2461\u3000\u521d\u671f\u6709\u5bb3\u6027\u60c5\u5831\u53d6\u5f97\u306e\u305f\u3081\u306e\u4f4e\u30b3\u30b9\u30c8\u30fb\u7c21\u4fbf\u306a\u6709\u5bb3\u6027\u8a55\u4fa1\u6280\u8853\u306e\u69cb\u7bc9<\/h3>\n<h5 id=\"2a\">\u2461(a) \u5438\u5165\u66b4\u9732\u8a66\u9a13\u3068\u6c17\u7ba1\u5185\u6295\u4e0e\u8a66\u9a13\u306e\u6bd4\u8f03\u691c\u8a0e<\/h5>\n<p>\u5b9f\u65bd\u6a5f\u95a2\uff1a\u7523\u696d\u533b\u79d1\u5927\u5b66 \u7523\u696d\u751f\u614b\u79d1\u5b66\u7814\u7a76\u6240<\/p>\n<p>Morimoto Y, Izumi H, Yoshiura Y, Tomonaga T, Oyabu T, Myojo T, Kawai K, Yatera K, Shimada M, Kubo M, Yamamoto K, Kitajima S, Kuroda E, Kawaguchi K, Sasaki T. Evaluation of pulmonary toxicity of well-dispersed zinc oxide nanoparticles following intratracheal instillation and inhalation. Int J Mol Sci 2016 Aug 1:17(8).<\/p>\n<p>Morimoto Y, Izumi H, Yoshiura Y, Fujishima K, Yatera K, Yamamoto K. Usefulness of Intratracheal Instillation Studies for Estimating Nanoparticle-Induced Pulmonary Toxicity. Int J Mol Sci. 2016 Jan 27;17(2).<\/p>\n<p>Morimoto Y, Izumi H, Yoshiura Y, Tomonaga T, Lee BW, Okada T, Oyabu T, Myojo T, Kawai K, Yatera K, Shimada M, Kubo M, Yamamoto K, Kitajima S, Kuroda E, Horie M, Kawaguchi K, Sasaki T. Comparison of pulmonary inflammatory responses following intratracheal instillation and inhalation of nanoparticles. Nanotoxicology. 2016 10(5) 607-618.<\/p>\n<p>Oyabu T, Morimoto Y, Izumi H, Yoshiura Y, Tomonaga T, Lee BW, Okada T, Myojo T, Shimada M, Kubo M, Yamamoto K, Kawaguchi K, Sasaki T. Comparison between whole-body inhalation and nose-only inhalation on the deposition and health effects of nanoparticles Environ Health Prev Med 2016 Jan21(1) 42-48.<\/p>\n<p>Horie M, Yoshiura Y, Izumi H, Oyabu T, Tomonaga T, Okada T, Lee BW, Myojo T, Kubo M, Shimada M, Morimoto Y. Comparison of the Pulmonary Oxidative Stress Caused by Intratracheal Instillation and Inhalation of NiO Nanoparticles when Equivalent Amounts of NiO Are Retained in the Lung. Antioxidants (Basel). 2016 Jan 18;5(1).<\/p>\n<p>Morimoto Y, Izumi H, Yoshiura Y, Tomonaga T, Oyabu T, Myojo T, Kawai K, Yatera K, Shimada M, Kubo M, Yamamoto K, Kitajima S, Kuroda E, Kawaguchi K, Sasaki T. Pulmonary toxicity of well-dispersed cerium oxide nanoparticles following intratracheal instillation and inhalation. J Nanopart Res 2015;17(11):442.<\/p>\n<p>Yoshiura Y, Izumi H, Oyabu T, Hashiba M, Kambara T, Mizuguchi Y, Lee BW, Okada T, Tomonaga T, Myojo T, Yamamoto K, Kitajima S, Horie M, Kuroda E, Morimoto Y. Pulmonary toxicity of well-dispersed titanium dioxide nanoparticles following intratracheal instillation. J Nanopart Res. 2015;17(6):241.<\/p>\n<p>Morimoto Y, Izumi H, Kuroda E (2014). Significance of persistent inflammation in respiratory disorder induced by nanoparticles. J Immunol Res. 2014, ID 962871.<\/p>\n<p>\u68ee\u672c \u6cf0\u592b\uff0c\u548c\u6cc9 \u5f18\u4eba\uff0c\u53cb\u6c38 \u6cf0\u4ecb (2014). \u30ca\u30ce\u7c92\u5b50\u306e\u751f\u4f53\u5f71\u97ff. \u547c\u5438\u5668\u5185\u79d1. 25(6), 571-577.<\/p>\n<p>\u68ee\u672c \u6cf0\u592b\uff0c\u548c\u6cc9 \u5f18\u4eba\uff0c\u5c71\u672c \u548c\u5f18 (2014). \u30ca\u30ce\u30de\u30c6\u30ea\u30a2\u30eb\u306e\u5065\u5eb7\u5f71\u97ff\u306b\u95a2\u3059\u308b\u73fe\u72b6\u3068\u5bfe\u7b56. \u65e5\u672c\u81e8\u5e8a. 72(2), 353-360.<\/p>\n<p>\u68ee\u672c \u6cf0\u592b\uff0c\u548c\u6cc9 \u5f18\u4eba (2014). \u300c\u30ca\u30ce\u7c92\u5b50\u3068\u547c\u5438\u5668\u75be\u60a3\u300d. Annual Review \u547c\u5438\u5668 2014. \u4e2d\u5916\u533b\u5b66\u793e. 119-126.<\/p>\n<p>\u68ee\u672c \u6cf0\u592b\uff0c\u5800\u6c5f \u7950\u7bc4\uff0c\u5317\u5cf6 \u4fe1\u4e00\uff0c\u798f\u5cf6 \u662d\u6cbb\uff0c\u6b66\u6797 \u4ea8 (2013). \u5de5\u696d\u7528\u30ca\u30ce\u6750\u6599\u306e\u6709\u5bb3\u6027\u8a55\u4fa1\u306b\u5411\u3051\u305f\u6c17\u7ba1\u5185\u6295\u4e0e\u8a66\u9a13\u3068\u5438\u5165\u66b4\u9732\u8a66\u9a13\u306e\u6240\u898b\u306e\u6bd4\u8f03. \u65e5\u672c\u885b\u751f\u5b66\u96d1\u8a8c. 68(3), 161-167.<\/p>\n<p>\u674e \u4e91\u5584\u30fb\u5927\u6d25\u5c71 \u7950\u5b50\u30fb\u5ddd\ufa11 \u7950\u4e5f\u30fb\u68ee\u672c \u6cf0\u592b\u30fb\u6cb3\u4e95 \u4e00\u660e\uff1a\u30ca\u30ce\u7c92\u5b50\u306b\u3088\u308b\u30e9\u30c3\u30c8\u80ba\u7d44\u7e54\u306e\u9178\u5316\u7684DNA\u640d\u50b7 \u65e5\u672c\u74b0\u5883\u5909\u7570\u539f\u5b66\u4f1a\u7b2c44\u56de\u5927\u4f1a\uff0e\u65e5\u672c\u74b0\u5883\u5909\u7570\u539f\u5b66\u4f1a(JEMS)\u7b2c44\u56de\u5927\u4f1a(\u798f\u5ca1)\u30d7\u30ed\u30b0\u30e9\u30e0\u30fb\u8981\u65e8\u96c6\uff0e136\uff0e(\u798f\u5ca1, 2015\u5e7411\u670827\u65e5\uff5e28\u65e5)\uff0e<\/p>\n<p>Izumi, H.\u30fbYoshiura Y.\u30fbTomonaga, T.\u30fbLee, B.\u30fbOkada, T.\u30fbOyabu, T.\u30fbMyojo, T.\u30fbShimada, M.\u30fbKubo, M.\u30fbYamamoto, K.\u30fbKitajima, S.\u30fbMorimoto, Y: Gene expression profile of pulmonary inflammation in rat lung induced by nickel oxide nanoparticles following intratracheal instillation ERS INTERNATIONAL CONGRESS 2015. European Respiratory Society Abstracts-Amsterdam 2015. (\u30a2\u30e0\u30b9\u30c6\u30eb\u30c0\u30e0;\u30aa\u30e9\u30f3\u30c0, 2015\u5e749\u67086 \u65e5\uff5e10\u65e5)\uff0e<\/p>\n<p>Kawai, K.\u30fbLi, Y.\u30fbKawasaki, Y.\u30fbMorimoto, Y.\u00a0 Oxidative DNA damage in rat lung after exposure to cerium oxide nanoparticles Amsterdam RAI\u306b\u3066\u3001ERS INTERNATIONAL CONGRESS 2015\uff0e European Respiratory Society Abstracts-Amsterdam 2015. (\u30a2\u30e0\u30b9\u30c6\u30eb\u30c0\u30e0;\u30aa\u30e9\u30f3\u30c0, 2015\u5e749\u67086 \u65e5\uff5e10\u65e5)\uff0e<\/p>\n<p>Morimoto, Y.\u30fbIzumi, H.\u30fbYoshiura Y.\u30fbTomonaga, T.\u30fbOyabu, T.\u30fbMyojo, T.\u30fbShimada, M.\u30fbKubo, M.\u30fbYamamoto, M.\u30fbKitajima, S : Pulmonary toxicity of cerium oxide nanoparticle following intratracheal instillation and inhalation of nanoparticles ERS INTERNATIONAL CONGRESS 2015. European Respiratory Society Abstracts-Amsterdam 2015. (\u30a2\u30e0\u30b9\u30c6\u30eb\u30c0\u30e0;\u30aa\u30e9\u30f3\u30c0, 2015\u5e749\u67086 \u65e5\uff5e10\u65e5).<\/p>\n<p>Oyabu, T.\u30fbMorimoto, Y.\u30fbShimada, M.\u30fbKubo, M.\u30fbLee, B.\u30fbOkada, T.\u30fbIzumi, H.\u30fbYoshiura Y.\u30fbMyojo, T. Deposition and pulmonary effect of nanoparticle in whole body inhalation study and in nose only inhalation study ERS INTERNATIONAL CONGRESS 2015. European Respiratory Society Abstracts-Amsterdam 2015. (\u30a2\u30e0\u30b9\u30c6\u30eb\u30c0\u30e0;\u30aa\u30e9\u30f3\u30c0, 2015\u5e749\u67086 \u65e5\uff5e10\u65e5)\uff0e<\/p>\n<p>\u5409\u6d66 \u7531\u8cb4\u5b50\u30fb\u548c\u6cc9 \u5f18\u4eba\u30fb\u53cb\u6c38 \u6cf0\u4ecb\u30fb\u5ca1\u7530 \u5d07\u9867\u30fb\u674e \u79c9\u96e8\u30fb\u85e4\u5d8b\u3051\u3044\u30fb\u5927\u85ea \u8cb4\u5b50\u30fb\u660e\u661f \u654f\u5f66\u30fb\u68ee\u672c \u6cf0\u592b\uff1a\u5de5\u696d\u7528\u30ca\u30ce\u6750\u6599\u306e\u6709\u5bb3\u6027\u8a55\u4fa1\u306b\u304a\u3051\u308bLDH\u306e\u6709\u7528\u6027\u5e73\u621027\u5e74\u5ea6\u65e5\u672c\u7523\u696d\u885b\u751f\u5b66\u4f1a \u4e5d\u5dde\u5730\u65b9\u4f1a\u5b66\u4f1a\uff0e\u5e73\u621027\u5e74\u5ea6\u65e5\u672c\u7523\u696d\u885b\u751f\u5b66\u4f1a\u3000\u4e5d\u5dde\u5730\u65b9\u4f1a\u5b66\u4f1a\u6284\u9332\u96c6.14.(\u9e7f\u5150\u5cf6,2015\u5e747\u670811\u65e5\uff5e12\u65e5).<\/p>\n<p>\u68ee\u672c \u6cf0\u592b\u30fb\u548c\u6cc9 \u5f18\u4eba\u30fb\u5409\u6d66 \u7531\u8cb4\u5b50\u30fb\u53cb\u6c38 \u6cf0\u4ecb\u30fb\u5927\u85ea \u8cb4\u5b50\u30fb\u660e\u661f \u654f\u5f66\u30fb\u5cf6\u7530 \u5b66\u30fb\u4e45\u4fdd \u512a\u30fb\u5c71\u672c \u548c\u5f18\u30fb\u5317\u5cf6 \u4fe1\u4e00\uff1a\u6c17\u7ba1\u5185\u6ce8\u5165\u8a66\u9a13\u3068\u5438\u5165\u66b4\u9732\u8a66\u9a13\u306b\u3088\u308b\u9178\u5316\u30bb\u30ea\u30a6\u30e0\u30ca\u30ce\u7c92\u5b50\u306e\u708e\u75c7\u80fd\u306e\u691c\u8a0e\u3000\u7b2c42\u56de\u3000\u65e5\u672c\u6bd2\u6027\u5b66\u4f1a\u5b66\u8853\u5e74\u4f1a\uff0eJ Toxicol Sci.40(Suppl),S176\uff0e(\u91d1\u6ca2,2015\u5e746\u670829\u65e5,30\u65e5,7\u67081\u65e5)\uff0e<\/p>\n<p>Oyabu, T.\u30fbMorimoto, Y.\u30fbIzumi, H.\u30fbTomonaga, T.\u30fbYoshiura Y.\u30fbShimada, M.\u30fbKubo, M.\u30fbMyojo, T : Comparison of biopersistences of NiO nanoparticles between in inhalation and intratracheal instillation studies 2015 Asian Aerosol Conference. 9<sup>th <\/sup>Asian Aerosol Conference Program. 103. (\u91d1\u6ca2,2015\u5e746\u670824\u65e5\uff5e27\u65e5).<\/p>\n<p>\u5409\u6d66 \u7531\u8cb4\u5b50\u30fb\u548c\u6cc9 \u5f18\u4eba\u30fb\u53cb\u6c38 \u6cf0\u4ecb\u30fb\u5927\u85ea \u8cb4\u5b50\u30fb\u5ca1\u7530 \u5d07\u9867\u30fb\u660e\u661f \u654f\u5f66\u30fb\u68ee\u672c \u6cf0\u592b\uff1a\u6c17\u7ba1\u5185\u6ce8\u5165\u8a66\u9a13\u306b\u3088\u308b\u4e8c\u9178\u5316\u30c1\u30bf\u30f3\u30ca\u30ce\u7c92\u5b50\u306e\u6709\u5bb3\u6027\u8a55\u4fa1\u3000\u7b2c88\u56de\u3000\u65e5\u672c\u7523\u696d\u885b\u751f\u5b66\u4f1a\uff0e\u7b2c88\u56de\u65e5\u672c\u7523\u696d\u885b\u751f\u5b66\u4f1a\u8b1b\u6f14\u96c6.\u7523\u696d\u885b\u751f\u5b66\u96d1\u8a8c\uff0e57(\u81e8\u6642\u5897\u520a\u53f7)426\uff0e(\u5927\u962a,2015\u5e745\u670813\u65e5\uff5e16\u65e5)\uff0e<\/p>\n<p>\u5927\u85ea \u8cb4\u5b50\u30fb\u68ee\u672c \u6cf0\u592b\u30fb\u548c\u6cc9 \u5f18\u4eba\u30fb\u5ca1\u7530 \u5d07\u9867\u30fb\u53cb\u6c38 \u6cf0\u4ecb\u30fb\u5409\u6d66 \u7531\u8cb4\u5b50\u30fb\u660e\u661f \u654f\u5f66\uff1a\u5438\u5165\u66dd\u9732\u8a66\u9a13\u304a\u3088\u3073\u6c17\u7ba1\u5185\u6ce8\u5165\u8a66\u9a13\u306b\u304a\u3051\u308b\u30ca\u30ce\u7c92\u5b50\u306e\u80ba\u5185\u6ede\u7559\u6027\u3000\u7b2c88\u56de\u3000\u65e5\u672c\u7523\u696d\u885b\u751f\u5b66\u4f1a\uff0e\u7b2c88\u56de\u65e5\u672c\u7523\u696d\u885b\u751f\u5b66\u4f1a\u8b1b\u6f14\u96c6.\u7523\u696d\u885b\u751f\u5b66\u96d1\u8a8c\uff0e57(\u81e8\u6642\u5897\u520a\u53f7)426\uff0e (\u5927\u962a,2015\u5e745\u670813\u65e5\uff5e16\u65e5)\uff0e<\/p>\n<p>\u548c\u6cc9 \u5f18\u4eba\u30fb\u5409\u6d66 \u7531\u8cb4\u5b50\u30fb\u53cb\u6c38 \u6cf0\u4ecb\u30fb\u5927\u85ea \u8cb4\u5b50\u30fb\u660e\u661f \u654f\u5f66\u30fb\u5ca1\u7530 \u5d07\u9867\u30fb\u68ee\u672c \u6cf0\u592b\uff1a\u9178\u5316\u30cb\u30c3\u30b1\u30eb\u306e\u80ba\u6709\u5bb3\u6027\u3092\u8a55\u4fa1\u3059\u308b\u907a\u4f1d\u5b50\u306e\u63a2\u7d22\u3000\u7b2c88\u56de\u3000\u65e5\u672c\u7523\u696d\u885b\u751f\u5b66\u4f1a\uff0e\u7b2c88\u56de\u65e5\u672c\u7523\u696d\u885b\u751f\u5b66\u4f1a\u8b1b\u6f14\u96c6.\u7523\u696d\u885b\u751f\u5b66\u96d1\u8a8c\uff0e57(\u81e8\u6642\u5897\u520a\u53f7)423\uff0e(\u5927\u962a,2015\u5e745\u670813\u65e5\uff5e16\u65e5)\uff0e<\/p>\n<p>\u68ee\u672c \u6cf0\u592b\u30fb\u548c\u6cc9 \u5f18\u4eba\u30fb\u5409\u6d66 \u7531\u8cb4\u5b50\u30fb\u53cb\u6c38 \u6cf0\u4ecb\u30fb\u5927\u85ea \u8cb4\u5b50\u30fb\u5ca1\u7530 \u5d07\u9867\u30fb\u660e\u661f \u654f\u5f66\uff1a\u5de5\u696d\u7528\u30ca\u30ce\u6750\u6599\u306e\u6709\u5bb3\u6027\u8a55\u4fa1\u6c17\u7ba1\u5185\u6295\u4e0e\u8a66\u9a13\u304c\u5438\u5165\u6bd2\u6027\u8a55\u4fa1\u306e\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u8a66\u9a13\u3068\u3057\u3066\u6709\u7528\u6027\u3000\u7b2c88\u56de\u3000\u65e5\u672c\u7523\u696d\u885b\u751f\u5b66\u4f1a\uff0e\u7b2c88\u56de\u65e5\u672c\u7523\u696d\u885b\u751f\u5b66\u4f1a\u8b1b\u6f14\u96c6.\u7523\u696d\u885b\u751f\u5b66\u96d1\u8a8c\uff0e57(\u81e8\u6642\u5897\u520a\u53f7)251\uff0e(\u5927\u962a,2015\u5e745\u670813\u65e5\uff5e16\u65e5)\uff0e<\/p>\n<p>\u548c\u6cc9 \u5f18\u4eba\u30fb\u68ee\u672c \u6cf0\u592b\uff1a\u30ca\u30ce\u7c92\u5b50\u3092\u7528\u3044\u305f\u6c17\u7ba1\u5185\u6ce8\u5165\u8a66\u9a13\u3068\u5438\u5165\u66b4\u9732\u8a66\u9a13\u306b\u3088\u308b\u80ba\u708e\u75c7\u306e\u6bd4\u8f03\u3000\u7b2c\uff17\uff13\u56de\u65e5\u672c\u764c\u5b66\u4f1a\u5b66\u8853\u7dcf\u4f1a\uff0e\u7b2c\uff17\uff13\u56de\u65e5\u672c\u764c\u5b66\u4f1a\u5b66\u8853\u7dcf\u4f1a\u3000PROGRAM\uff0e268\uff0e(\u6a2a\u6d5c,2014\u5e749\u670825\u65e5\uff5e27\u65e5)\uff0e<\/p>\n<p>Kawai, K.\u30fbLi, Y.\u30fbKawasaki, Y.\u30fbMorimoto, Y. \u00a0Oxidative stress in rat lung after exposure to titanium dioxide and nickel oxide nanoparticles. ERS International Congress 2014\uff0eERS INTERNATIONAL CONGRESS \u00a02014 CONGRESS GUIDE. 299. (\u30df\u30e5\u30f3\u30d8\u30f3;\u30c9\u30a4\u30c4, 2014\u5e749\u67086\u65e5\uff5e10\u65e5)\uff0e<\/p>\n<p>Izumi, H.\u30fbMorimoto, Y.\u30fbHorie, M.\u30fbYoshiura,Y.\u30fbTomonaga, T.\u30fbLee, B.\u30fbOkada, T.\u30fbOyabu, T.\u30fbMyojo, T.\u30fbShimada,M.\u30fbKubo,M.\u30fbYamamoto,K.\u30fbKitajima,S. Comparison of pulmonary inflammatory responses between intratracheal instillation and inhalation of nanoparticles. ERS International Congress 2014.\u00a0INTERNATIONAL CONGRESS 2014 CONGRESS GUIDE. 123. (\u30df\u30e5\u30f3\u30d8\u30f3;\u30c9\u30a4\u30c4, 2014\u5e749\u67086\u65e5\uff5e10\u65e5\uff09\uff0e<\/p>\n<p>Oyabu, T.\u30fbMorimoto, Y.\u30fbLee, B.\u30fbOkada, T.\u30fbIzumi, H.\u30fbTomonaga, T.\u30fbYoshiura, M.\u30fbShimada, M.\u30fbKudo, T.\u30fbMyojo, T.\u00a0 Biopersistence of nanoparticle in inhalation and intratracheal instillation studies for hazard assessment.\u00a0ERS International Congress 2014.\u00a0INTERNATIONAL CONGRESS 2014 CONGRESS GUIDE. 123. (\u30df\u30e5\u30f3\u30d8\u30f3;\u30c9\u30a4\u30c4, 2014\u5e749\u67086\u65e5\uff5e10\u65e5\uff09\uff0e<\/p>\n<p>Li, Y.\u30fbSong M\u30fbMorimoto, Y.\u30fbKawai, K: Titanium dioxide and nickel oxide nanoparticles induce oxidative DNA damage in the rat lung. The 21st Asian Conference on Occupational Health\uff0eACOH\u30002014 FUKUOKA JAPAN Program and Abstract Book. 139. (\u798f\u5ca1, 2014\u5e749\u67082\u65e5\uff5e4\u65e5)\uff0e<\/p>\n<p>\u5927\u85ea \u8cb4\u5b50\u30fb\u68ee\u672c \u6cf0\u592b\u30fb\u5409\u6d66 \u7531\u8cb4\u5b50\u30fb\u674e \u79c9\u96e8\u30fb\u5ca1\u7530 \u5d07\u9867\u30fb\u5800\u6c5f \u7950\u7bc4\u30fb\u548c\u6cc9 \u5f18\u4eba\u30fb\u53cb\u6c38 \u6cf0\u4ecb\u30fb\u660e\u661f \u654f\u5f66\uff1a\u30ca\u30ce\u7c92\u5b50\u306e\u6709\u5bb3\u6027\u8a55\u4fa1\u306e\u305f\u3081\u306e\u5438\u5165\u66dd\u9732\u8a66\u9a13\u3068\u6c17\u7ba1\u5185\u6ce8\u5165\u8a66\u9a13\u306e\u540c\u6642\u8a66\u884c\u3000\u7b2c87\u56de\u3000\u65e5\u672c\u7523\u696d\u885b\u751f\u5b66\u4f1a\uff0e\u7b2c87\u56de\u65e5\u672c\u7523\u696d\u885b\u751f\u5b66\u4f1a\u8b1b\u6f14\u96c6.\u7523\u696d\u885b\u751f\u5b66\u96d1\u8a8c\uff0e56(\u81e8\u6642\u5897\u520a\u53f7)450\uff0e(\u5ca1\u5c71, 2014\u5e745\u670821\u65e5\uff5e24\u65e5)\uff0e<\/p>\n<p>\u68ee\u672c \u6cf0\u592b\u30fb\u548c\u6cc9 \u5f18\u4eba\u30fb\u5409\u6d66 \u7531\u8cb4\u5b50\u30fb\u53cb\u6c38 \u6cf0\u4ecb\u30fb\u5927\u85ea \u8cb4\u5b50\u30fb\u660e\u661f \u654f\u5f66\u30fb\u5ca1\u7530 \u5d07\u9867\u30fb\u674e \u79c9\u96e8\u30fb\u5317\u5cf6 \u4fe1\u4e00\uff1a\u5de5\u696d\u7528\u30ca\u30ce\u6750\u6599\u306e\u6709\u5bb3\u6027\u8a55\u4fa1-\u5438\u5165\u66b4\u9732\u8a66\u9a13\u306e\u4ee3\u66ff\u8a66\u9a13\u3068\u3057\u3066\u6c17\u7ba1\u5185\u6295\u4e0e\u8a66\u9a13\u306e\u6709\u7528\u6027\u3000\u7b2c87\u56de\u3000\u65e5\u672c\u7523\u696d\u885b\u751f\u5b66\u4f1a\uff0e\u7b2c87\u56de\u65e5\u672c\u7523\u696d\u885b\u751f\u5b66\u4f1a\u8b1b\u6f14\u96c6.\u7523\u696d\u885b\u751f\u5b66\u96d1\u8a8c\uff0e56\uff0e(\u81e8\u6642\u5897\u520a\u53f7)347\uff0e(\u5ca1\u5c71, 2014\u5e745\u670821\u65e5\uff5e24\u65e5)\uff0e<\/p>\n<p>\u68ee\u672c \u6cf0\u592b\uff0c\u5800\u6c5f \u7950\u7bc4\uff0c\u5317\u5cf6 \u4fe1\u4e00\uff0c\u798f\u5cf6 \u662d\u6cbb\uff0c\u6b66\u6797 \u4ea8 (2013). \u5de5\u696d\u7528\u30ca\u30ce\u6750\u6599\u306e\u6709\u5bb3\u6027\u8a55\u4fa1\u306b\u5411\u3051\u305f\u6c17\u7ba1\u5185\u6295\u4e0e\u8a66\u9a13\u3068\u5438\u5165\u66b4\u9732\u8a66\u9a13\u306e\u6240\u898b\u306e\u6bd4\u8f03. \u65e5\u672c\u885b\u751f\u5b66\u96d1\u8a8c. 68(3), 161-167.<\/p>\n<p>\u68ee\u672c \u6cf0\u592b\uff1a\u30ca\u30ce\u7269\u8cea\u306e\u5b89\u5168\u8a55\u4fa1-\u5438\u5165\u66b4\u9732\u8a66\u9a13\u3068\u6c17\u7ba1\u5185\u6ce8\u5165\u8a66\u9a13\u306e\u5f79\u5272\u3000\u7b2c26\u56de\u3000\u65e5\u672c\u52d5\u7269\u5b9f\u9a13\u4ee3\u66ff\u6cd5\u5b66\u4f1a\uff0e\u65e5\u672c\u52d5\u7269\u5b9f\u9a13\u4ee3\u66ff\u6cd5\u5b66\u4f1a\u7b2c26\u56de\u5927\u4f1a\u3000\u30d7\u30ed\u30b0\u30e9\u30e0\/\u8b1b\u6f14\u8981\u65e8\u96c6\uff0e72\uff0e(\u4eac\u90fd,2013\u5e7412\u670819\u65e5\uff5e21\u65e5)\uff0e<\/p>\n<p>Kawai, K.\u30fbLi, Y.\u30fbKasai, H.\u30fbMorimoto, Y.\u00a0 Titanium dioxide and nickel oxide nanoparticles induced oxidative DNA damage in the rat lung \u7b2c8\u56de\u3000\u30a2\u30b8\u30a2\u30a8\u30a2\u30ed\u30be\u30eb\u4f1a\u8b70\uff0e8<sup>th<\/sup><sup>\u3000<\/sup>Asian Aerosol Conference Poster Presentation Abstracts. 20. (\u30b7\u30c9\u30cb\u30fc;\u30aa\u30fc\u30b9\u30c8\u30e9\u30ea\u30a2, 2013\u5e7412\u67082\u65e5\uff5e5\u65e5)\uff0e<\/p>\n<p>Oyabu, T.\u30fbMorimoto, Y.\u30fbHorie, M.\u30fbYoshiura, Y\u30fbShimada, M\u30fbKubo, M\u30fbLee, B.\u30fbOkada, T.\u30fbMyojo, T.\u00a0 Coincidental study of inhalation and intratracheal instillation for hazard assessment of nanoparticles.\u3000EAC\u30002013 European\u3000Aerosol Conference\uff0eEAC 2013 PRAGUE Handbook. 98. (\u30c1\u30a7\u30b3, 2013\u5e749\u67081\u65e5\uff5e6\u65e5)\uff0e<\/p>\n<p>\u5800\u6c5f \u7950\u7bc4\u30fb\u5409\u6d66 \u7531\u8cb4\u5b50\u30fb\u674e \u79c9\u96e8\u30fb\u5ca1\u7530 \u5d07\u9867\u30fb\u5927\u85ea \u8cb4\u5b50\u30fb\u660e\u661f \u654f\u5f66\u30fb\u68ee\u672c \u6cf0\u592b\u30fb\u4e45\u4fdd \u512a\u30fb\u5cf6\u7530 \u5b66\uff1a\u30ca\u30ce\u7c92\u5b50\u306e\u6c17\u7ba1\u5185\u6ce8\u5165\u3068\u5438\u5165\u66b4\u9732\u306b\u3088\u308b\u80ba\u5185\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306e\u6bd4\u8f03\u3000\u7b2c30\u56de\u3000\u30a8\u30a2\u30ed\u30be\u30eb\u79d1\u5b66\u30fb\u6280\u8853\u7814\u7a76\u8a0e\u8ad6\u4f1a\uff0e\u7b2c30\u56de\u3000\u30a8\u30a2\u30ed\u30be\u30eb\u79d1\u5b66\u30fb\u6280\u8853\u7814\u7a76\u8a0e\u8ad6\u4f1a\uff0e\u6284\u9332\u96c6\uff0e23\uff0e(\u4eac\u90fd,2013\u5e748\u670827\u65e5\uff5e29\u65e5)\uff0e<\/p>\n<p>\u5800\u6c5f \u7950\u7bc4\u30fb\u5409\u6d66 \u7531\u8cb4\u5b50\u30fb\u674e \u79c9\u96e8\u30fb\u5ca1\u7530 \u5d07\u9867\u30fb\u5927\u85ea \u8cb4\u5b50\u30fb\u660e\u661f \u654f\u5f66\u30fb\u68ee\u672c \u6cf0\u592b\uff1a\u30ca\u30ce\u7c92\u5b50\u306e\u6c17\u7ba1\u5185\u6ce8\u5165\u8a66\u9a13\u3068\u5438\u5165\u66dd\u9732\u8a66\u9a13\u306b\u3088\u308b\u80ba\u53cd\u5fdc\u306e\u6bd4\u8f03-\u540c\u7b49\u306e\u80ba\u5185\u4fdd\u6301\u91cf\u306b\u3088\u308b\u80ba\u50b7\u5bb3\u30fb\u708e\u75c7\u306e\u691c\u8a0e-\u7b2c40\u56de\u65e5\u672c\u6bd2\u6027\u5b66\u4f1a\u5b66\u8853\u5e74\u4f1a\uff0eJ Toxicol Sci.38(Suppl),S267\uff0e(\u5343\u8449,2013\u5e746\u670817\u65e5\uff5e19\u65e5)\uff0e<\/p>\n<p>\u68ee\u672c \u6cf0\u592b\u30fb\u5800\u6c5f \u7950\u7bc4\u30fb\u5927\u85ea \u8cb4\u5b50\u30fb\u674e \u79c9\u96e8\u30fb\u5ca1\u7530 \u5d07\u9867\u30fb\u660e\u661f \u654f\u5f66\uff1a\u4e8c\u9178\u5316\u30c1\u30bf\u30f3\u30ca\u30ce\u7c92\u5b50\u306e\u80ba\u5185\u708e\u75c7\u80fd\u3000\u7b2c86\u56de\u65e5\u672c\u7523\u696d\u885b\u751f\u5b66\u4f1a\uff0e\u7b2c88\u56de\u65e5\u672c\u7523\u696d\u885b\u751f\u5b66\u4f1a\u8b1b\u6f14\u96c6.\u7523\u696d\u885b\u751f\u5b66\u96d1\u8a8c\uff0e55(\u81e8\u6642\u5897\u520a\u53f7)518\uff0e(\u611b\u5a9b,2013\u5e745\u670814\u65e5\uff5e17\u65e5)\uff0e<\/p>\n<h5 id=\"2b-1\">\u2461(b-1) \u6c17\u7ba1\u5185\u6295\u4e0e\u8a66\u9a13\u306e\u6a19\u6e96\u5316\u306b\u95a2\u3059\u308b\u691c\u8a0e\uff1a\u624b\u6280\u306e\u6a19\u6e96\u5316\u306b\u95a2\u3059\u308b\u691c\u8a0e<\/h5>\n<p>\u5b9f\u65bd\u6a5f\u95a2\uff1a\u5316\u5b66\u7269\u8cea\u8a55\u4fa1\u7814\u7a76\u6a5f\u69cb<\/p>\n<p>Tsubokura Y, Kobayashi T, Oshima Y, Hashizume N, Nakai M, Ajimi S and Imatanaka N (2016). Effects of pentobarbital, isoflurane, or medetomidine-midazolam-butorphanol anesthesia on bronchoalveolar lavage fluid and blood chemistry in rats. The Journal of Toxicological Sciences. 41.<\/p>\n<p>\u5c0f\u6797 \u4fca\u592b\uff0c\u5927\u5d8b \u6d69\uff0c\u576a\u5009 \u9756\u7950\uff0c\u83ca\u6c60 \u7d14\u4e00\uff0c\u6a4b\u722a \u76f4\u6a39\uff0c\u4e95\u4e0a \u7fa9\u4e4b\uff0c\u4e2d\u4e95 \u8aa0\uff0c\u5b89\u5fc3\u9662 \u7965\u4e09\uff0c\u53e4\u5ddd \u6d69\u592a\u90ce\uff0c\u4eca\u7530\u4e2d \u4f38\u54c9\uff0c\u576a\u5009\u9756\u7950 (2014). \u30ca\u30ce\u6750\u6599\u306e\u6c17\u7ba1\u5185\u6295\u4e0e\u8a66\u9a13\u306e\u8a66\u9a13\u6cd5\u6a19\u6e96\u5316\u306b\u5411\u3051\u305f\u691c\u8a0e\uff5e\u6295\u4e0e\u5668\u5177\u53ca\u3073\u6295\u4e0e\u6db2\u91cf\u306e\u5f71\u97ff\uff5e. \u7b2c41\u56de\u65e5\u672c\u6bd2\u6027\u5b66\u4f1a\u5b66\u8853\u5e74\u4f1a. J Toxicol Sci. 39 (Suppl), S266. (\u795e\u6238, 2014\u5e747\u67082\uff5e4\u65e5).<\/p>\n<p>\u576a\u5009 \u9756\u7950\uff0c\u5927\u5d8b \u6d69\uff0c\u5c0f\u6797 \u4fca\u592b\uff0c\u83ca\u6c60 \u7d14\u4e00\uff0c\u6a4b\u722a \u76f4\u6a39\uff0c\u4e95\u4e0a \u7fa9\u4e4b\uff0c\u4e2d\u4e95 \u8aa0\uff0c\u5b89\u5fc3\u9662 \u7965\u4e09\uff0c\u53e4\u5ddd \u6d69\u592a\u90ce\uff0c\u4eca\u7530\u4e2d \u4f38\u54c9\uff0c\u5c0f\u6797\u4fca\u592b (2014). \u30ca\u30ce\u6750\u6599\u306e\u6c17\u7ba1\u5185\u6295\u4e0e\u8a66\u9a13\u306e\u8a66\u9a13\u6cd5\u6a19\u6e96\u5316\u306b\u5411\u3051\u305f\u691c\u8a0e\uff5e\u89e3\u5256\u6642\u9ebb\u9154\u6cd5\u306e\u9055\u3044\u304cBALF\u691c\u67fb\u7d50\u679c\u306b\u4e0e\u3048\u308b\u5f71\u97ff\uff5e. \u7b2c41\u56de\u65e5\u672c\u6bd2\u6027\u5b66\u4f1a\u5b66\u8853\u5e74\u4f1a. J Toxicol Sci. 39 (Suppl), S338. (\u795e\u6238, 2014\u5e747\u67082\u65e5\uff5e4\u65e5).<\/p>\n<p>Kobayashi T, Oshima Y, Kikuchi J, Tsubokura Y, Hashizume N, Nakai M, Ajimi S, Imatanaka N, Furukawa F (2013). Effect of study conditions on the toxicity by intratracheal administration of nano TiO<sub>2<\/sub> in rats, 6th International Symposium on Nanotechnology, Occupational and Environmental Health. P-02-043. (Aichi, October 28-31, 2013).<\/p>\n<h5 id=\"2b-2\">\u2461(b-2) \u6c17\u7ba1\u5185\u6295\u4e0e\u8a66\u9a13\u306e\u6a19\u6e96\u5316\u306b\u95a2\u3059\u308b\u691c\u8a0e\uff1a\u5358\u56de\u6295\u4e0e\u3068\u8907\u6570\u56de\u6295\u4e0e\u306e\u6bd4\u8f03\u691c\u8a0e<\/h5>\n<p>\u5b9f\u65bd\u6a5f\u95a2\uff1a\u65e5\u672c\u30d0\u30a4\u30aa\u30a2\u30c3\u30bb\u30a4\u7814\u7a76\u30bb\u30f3\u30bf\u30fc<\/p>\n<p>\u59b9\u5c3e \u82f1\u6a39, \u52a0\u7d0d \u6d69\u548c, \u9234\u6728 \u6b63\u660e, \u8fd1\u85e4 \u3072\u3068\u307f, \u9ad8\u4fe1 \u5065\u53f8, \u6885\u7530 \u3086\u307f, \u76f8\u78ef \u6210\u654f, \u798f\u5cf6 \u662d\u6cbb (2016)\uff0e\u6c17\u7ba1\u652f\u80ba\u80de\u6d17\u6d44\u6db2\u691c\u67fb\u306b\u304a\u3051\u308b\u4e09\u7a2e\u6df7\u5408\u9ebb\u9154\u306e\u554f\u984c\u70b9. \u7523\u696d\u885b\u751f\u5b66\u96d1\u8a8c 58(1), 21-24.<\/p>\n<p>\u9234\u6728 \u6b63\u660e\uff0c\u52a0\u7d0d \u6d69\u548c\uff0c\u59b9\u5c3e \u82f1\u6a39\uff0c\u8fd1\u85e4 \u3072\u3068\u307f\uff0c\u6238\u8c37 \u5fe0\u96c4\uff0c\u9f4b\u85e4 \u7f8e\u4f50\u6c5f\uff0c\u5927\u897f \u8aa0, \u76f8\u78ef \u6210\u654f\uff0c\u798f\u5cf6 \u662d\u6cbb (2015). \u591a\u5c64\u30ab\u30fc\u30dc\u30f3\u30ca\u30ce\u30c1\u30e5\u30fc\u30d6\u306e\u6c17\u7ba1\u5185\u6295\u4e0e\u306b\u3088\u308b\u751f\u4f53\u5f71\u97ff\uff1a\u6295\u4e0e\u56de\u6570\u306e\u9055\u3044\u306b\u3088\u308b\u6bd4\u8f03. \u7b2c42\u56de\u65e5\u672c\u6bd2\u6027\u5b66\u4f1a\u5b66\u8853\u5e74\u4f1a\u8981\u65e8\u96c6. J Toxicol Sci. 40 (Suppl), S248. (\u91d1\u6ca2, 2015\u5e746\u670829\u65e5\uff5e7\u67081\u65e5).<\/p>\n<p>\u59b9\u5c3e \u82f1\u6a39, \u52a0\u7d0d \u6d69\u548c, \u8fd1\u85e4 \u3072\u3068\u307f, \u9ad8\u4fe1 \u5065\u53f8\uff0c\u6885\u7530 \u3086\u307f,\u3000\u76f8\u78ef \u6210\u654f, \u798f\u5cf6 \u662d\u6cbb (2015). BALF\u691c\u67fb\u306b\u304a\u3051\u308b\u9ebb\u9154\u6cd5\u306e\u691c\u8a0e3\u7a2e\u6df7\u5408\u9ebb\u9154\u306e\u554f\u984c\u70b9\u2010. \u7b2c88\u56de\u65e5\u672c\u7523\u696d\u885b\u751f\u5b66\u4f1a\u8b1b\u6f14\u96c6. \u7523\u696d\u885b\u751f\u5b66\u96d1\u8a8c. 57 (\u81e8\u6642\u5897\u520a\u53f7), 252. (\u5927\u962a, 2015\u5e745\u670813\u65e5\uff5e16\u65e5).<\/p>\n<p>\u9234\u6728 \u6b63\u660e\uff0c\u52a0\u7d0d \u6d69\u548c\uff0c\u59b9\u5c3e \u82f1\u6a39\uff0c\u8fd1\u85e4 \u3072\u3068\u307f\uff0c\u6238\u8c37 \u5fe0\u96c4\uff0c\u9f4b\u85e4 \u7f8e\u4f50\u6c5f\uff0c\u76f8\u78ef \u6210\u654f\uff0c\u798f\u5cf6 \u662d\u6cbb (2014). \u9178\u5316\u30cb\u30c3\u30b1\u30eb\u30ca\u30ce\u7c92\u5b50\u306e\u6c17\u7ba1\u5185\u6295\u4e0e\u306b\u3088\u308b\u751f\u4f53\u5f71\u97ff\uff1a\u6295\u4e0e\u56de\u6570\u306e\u9055\u3044\u306b\u3088\u308b\u6bd4\u8f03. \u7b2c41\u56de\u65e5\u672c\u6bd2\u6027\u5b66\u4f1a\u5b66\u8853\u5e74\u4f1a\u8981\u65e8\u96c6. J Toxicol Sci. 39 (Suppl), S338. (\u795e\u6238, 2014\u5e747\u67082\u65e5\uff5e4\u65e5).<\/p>\n<p>\u8fd1\u85e4 \u3072\u3068\u307f, \u6238\u8c37 \u5fe0\u96c4\uff0c\u52a0\u7d0d \u6d69\u548c, \u9234\u6728 \u6b63\u660e, \u59b9\u5c3e \u82f1\u6a39, \u76f8\u78ef \u6210\u654f, \u798f\u5cf6 \u662d\u6cbb (2014). \u9178\u5316\u30cb\u30c3\u30b1\u30eb\u30ca\u30ce\u7c92\u5b50\u306e\u30e9\u30c3\u30c8\u3078\u306e\u6c17\u7ba1\u5185\u6295\u4e0e\u306b\u3088\u308b\u80ba\u6bd2\u6027\uff1a\u6295\u4e0e\u56de\u6570\u306e\u9055\u3044\u306b\u3088\u308b\u691c\u8a0e\uff08BALF\u691c\u67fb). \u7b2c87\u56de\u65e5\u672c\u7523\u696d\u885b\u751f\u5b66\u4f1a\u8b1b\u6f14\u96c6. \u7523\u696d\u885b\u751f\u5b66\u96d1\u8a8c. 56 (\u81e8\u6642\u5897\u520a\u53f7), 450. (\u5ca1\u5c71, 2014\u5e745\u670821\u65e5\uff5e24\u65e5).<\/p>\n<p>\u59b9\u5c3e \u82f1\u6a39, \u52a0\u7d0d \u6d69\u548c, \u9234\u6728 \u6b63\u660e, \u9ad8\u4fe1 \u5065\u53f8, \u6885\u7530 \u3086\u307f, \u76f8\u78ef \u6210\u654f, \u798f\u5cf6 \u662d\u6cbb (2014). \u9178\u5316\u30cb\u30c3\u30b1\u30eb\u30ca\u30ce\u7c92\u5b50\u306e\u30e9\u30c3\u30c8\u3078\u306e\u6c17\u7ba1\u5185\u6295\u4e0e\u306b\u3088\u308b\u80ba\u6bd2\u6027\uff1a\u6295\u4e0e\u56de\u6570\u306e\u9055\u3044\u306b\u3088\u308b\u691c\u8a0e\uff08\u75c5\u7406\u7d44\u7e54\u5b66\u7684\u691c\u67fb). \u7b2c87\u56de\u65e5\u672c\u7523\u696d\u885b\u751f\u5b66\u4f1a\u8b1b\u6f14\u96c6. \u7523\u696d\u885b\u751f\u5b66\u96d1\u8a8c. 56 (\u81e8\u6642\u5897\u520a\u53f7), 449. (\u5ca1\u5c71, 2014\u5e745\u670821\u65e5\uff5e24\u65e5).<\/p>\n<p>\u59b9\u5c3e \u82f1\u6a39\uff0c\u52a0\u7d0d \u6d69\u548c\uff0c\u9234\u6728 \u6b63\u660e\uff0c\u5927\u897f \u8aa0\uff0c\u7b20\u4e95 \u8fb0\u4e5f\uff0c\u9ad8\u4fe1 \u5065\u53f8\uff0c\u6885\u7530 \u3086\u307f\uff0c\u76f8\u78ef \u6210\u654f\uff0c\u798f\u5cf6 \u662d\u6cbb (2013). \u30ca\u30ce\u30de\u30c6\u30ea\u30a2\u30eb\u306e\u751f\u4f53\u5f71\u97ff\u8a55\u4fa1\u306b\u304a\u3051\u308b\u6c17\u7ba1\u5185\u6295\u4e0e\u6cd5\u306e\u6709\u7528\u6027\u3068\u6d3b\u7528\u65b9\u6cd5. \u7b2c28\u56de\u767a\u764c\u75c5\u7406\u7814\u7a76\u4f1a. 25. (\u6c96\u7e04, 2013\u5e748\u670826\u65e5\uff5e28\u65e5).<\/p>\n<p>\u9234\u6728 \u6b63\u660e\uff0c\u52a0\u7d0d \u6d69\u548c\uff0c\u59b9\u5c3e \u82f1\u6a39\uff0c\u8fd1\u85e4 \u3072\u3068\u307f\uff0c\u6238\u8c37 \u5fe0\u96c4\uff0c\u9f4b\u85e4 \u7f8e\u4f50\u6c5f\uff0c\u76f8\u78ef \u6210\u654f\uff0c\u798f\u5cf6 \u662d\u6cbb (2013). \u4e8c\u9178\u5316\u30c1\u30bf\u30f3\u306e\u6c17\u7ba1\u5185\u6295\u4e0e\u306b\u3088\u308b\u751f\u4f53\u5f71\u97ff\uff1a\u52d5\u7269\u306e\u7cfb\u7d71\u306e\u9055\u3044\u306b\u3088\u308b\u6bd4\u8f03. \u7b2c40\u56de\u65e5\u672c\u6bd2\u6027\u5b66\u4f1a\u5b66\u8853\u5e74\u4f1a\u8981\u65e8\u96c6. J Toxicol Sci. 38 (Suppl), S352. (\u5343\u8449, 2013\u5e746\u670817\u65e5\uff5e19\u65e5).<\/p>\n<p>\u9234\u6728 \u6b63\u660e, \u52a0\u7d0d \u6d69\u548c, \u5c71\u5d0e \u4e00\u6cd5, \u8fd1\u85e4 \u3072\u3068\u307f, \u6238\u8c37 \u5fe0\u96c4, \u9f4b\u85e4 \u7f8e\u4f50\u6c5f, \u59b9\u5c3e \u82f1\u6a39, \u76f8\u78ef \u6210\u654f, \u798f\u5cf6 \u662d\u6cbb (2012). \u4e8c\u9178\u5316\u30c1\u30bf\u30f3\u306e\u6c17\u7ba1\u5185\u6295\u4e0e\u306b\u3088\u308b\u751f\u4f53\u5f71\u97ff\uff1a\u6295\u4e0e\u56de\u6570\u306e\u9055\u3044\u306b\u3088\u308b\u6bd4\u8f03. \u7b2c39\u56de\u65e5\u672c\u6bd2\u6027\u5b66\u4f1a\u5b66\u8853\u5e74\u4f1a\u8981\u65e8\u96c6. J Toxicol Sci. 37 (Suppl I), S228. (\u5bae\u57ce, 2012\u5e747\u670817\u65e5\uff5e19\u65e5).<\/p>\n<h5 id=\"2c\">\u2461(c) \u30a8\u30a2\u30ed\u30be\u30eb\u306e\u5b89\u5b9a\u767a\u751f\u624b\u6cd5\u306e\u69cb\u7bc9<\/h5>\n<p>\u5b9f\u65bd\u6a5f\u95a2\uff1a\u5e83\u5cf6\u5927\u5b66\u5927\u5b66\u9662\u5de5\u5b66\u7814\u7a76\u9662<\/p>\n<p>Kubo M, Nakaoka A, Morimoto K, Shimada M, Horie M, Morimoto Y, Sasaki T (2014), Aerosol Generation by a Spray-Drying Technique Under Coulomb Explosion and Rapid Evaporation for the Preparation of Aerosol Particles for Inhalation Tests. Aerosol Science and Technology. 48(7), 698-705.<\/p>\n<p>\u5c0f\u7d2b \u771f\u53cb\u5b50\uff0c\u68ee\u672c \u548c\u5e0c\uff0c\u4e45\u4fdd \u512a\uff0c\u5cf6\u7530 \u5b66. \u6db2\u6ef4\u7834\u7815\u306b\u3088\u308b\u30ca\u30ce\u7c92\u5b50\u30a8\u30a2\u30ed\u30be\u30eb\u767a\u751f\u306b\u304a\u3051\u308b\u30a4\u30aa\u30f3\u6fc3\u5ea6\u306e\u5f71\u97ff. \u7b2c17\u56de\u5316\u5b66\u5de5\u5b66\u4f1a\u5b66\u751f\u767a\u8868\u4f1a\uff08\u5fb3\u5cf6\u5927\u4f1a). I12.\uff08\u5fb3\u5cf6\uff0c2015\u5e743\u67087\u65e5).<\/p>\n<p>\u5cf6\u7530 \u5b66\uff0c\u4e45\u4fdd \u512a (2014). \u300c\u7b2c4\u7ae0 \u85ac\u5264\u306e\u7d4c\u80ba\u30c7\u30ea\u30d0\u30ea\u30fc\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u30c7\u30d0\u30a4\u30b9\u958b\u767a\u7b2c2\u7bc0 \u7d4c\u80ba\u30c7\u30d0\u30a4\u30b9\uff0f\u5438\u5165\u7642\u6cd5\u306e\u6027\u80fd\u8a55\u4fa1\u53ca\u3073\u5b89\u5168\u6027 \uff3b\uff14\uff3d\u5438\u5165\u8a66\u9a13\u306e\u305f\u3081\u306e\u7c92\u5b50\u5206\u6563\u6cd5\u300d. \u6ce8\u5c04\u5264\u30fb\u7d4c\u53e3\u88fd\u5264\u306b\u4ee3\u308f\u308b\u65b0\u3057\u3044\u85ac\u5264\u6295\u4e0e\u30c7\u30d0\u30a4\u30b9\u306e\u958b\u767a. \u6280\u8853\u60c5\u5831\u5354\u4f1a.<\/p>\n<p>Shimada M, Kubo M, Horie M, Morimoto Y, Sasaki T (2014). Preparation of Aerosol Particles for Inhalation Tests by Spray-drying Combined with Droplet Breakup. International Aerosol Conference. SS07-2. (Busan, Korea, August 28\u2013September 2, 2014).<\/p>\n<p>\u4e45\u4fdd \u512a\uff0c\u68ee\u672c \u548c\u5e0c\uff0c\u4e2d\u5ca1 \u4eae\uff0c\u5cf6\u7530 \u5b66\uff0c\u5800\u6c5f \u7950\u7bc4\uff0c\u68ee\u672c \u6cf0\u592b\uff0c\u4f50\u3005\u6728 \u6bc5. \u5674\u9727\u4e7e\u71e5\u6cd5\u306b\u3088\u308b\u5438\u5165\u66b4\u9732\u8a66\u9a13\u7528\u30ca\u30ce\u7c92\u5b50\u30a8\u30a2\u30ed\u30be\u30eb\u306e\u8abf\u88fd. \u5316\u5b66\u5de5\u5b66\u4f1a\u7b2c79\u5e74\u4f1a. R201\uff08\u5c90\u961c\uff0c2014\u5e743\u670818\uff5e20\u65e5).<\/p>\n<p>\u68ee\u672c \u548c\u5e0c\uff0c\u4e2d\u5ca1 \u4eae\uff0c\u4e45\u4fdd \u512a\uff0c\u5cf6\u7530 \u5b66. \u5674\u9727\u4e7e\u71e5\u6cd5\u306b\u304a\u3051\u308b\u6db2\u6ef4\u7834\u7815\u73fe\u8c61\u306b\u53ca\u307c\u3059\u30a4\u30aa\u30f3\u6fc3\u5ea6\u306e\u5f71\u97ff. \u5316\u5b66\u5de5\u5b66\u4f1a\u4e2d\u56fd\u56db\u56fd\u652f\u90e8\u5927\u4f1a\u3000\u5b87\u90e8\u5927\u4f1a. B10. (\u5c71\u53e3\uff0c2013\u5e7412\u670813\u65e5).<\/p>\n<p>Shimada M, Kubo M, Horie M, Morimoto Y, Sasaki T. Spray-drying Technique with Droplet Breakup for Preparing Test Aerosol Particles for Inhalation Experiments. 8th Asian Aerosol Conference. 2C-1. (Sydney, Australia, December 2-5, 2013).<\/p>\n<p>Kubo M, Shimada M, Horie M, Morimoto Y, Sasaki T. Preparation of nano-sized aerosol particles by a spray-drying technique with breaking up of droplets. 6th International Symposium on Nanotechnology, Occupational and Environmental Health. O-29-A-10. (Aichi, October 28-31, 2013).<\/p>\n<p>\u4e2d\u5ca1 \u4eae\uff0c\u68ee\u672c \u548c\u5e0c\uff0c\u4e45\u4fdd \u512a\uff0c\u5cf6\u7530 \u5b66\uff0c\u5800\u6c5f \u7950\u7bc4\uff0c\u68ee\u672c \u6cf0\u592b\uff0c\u4f50\u3005\u6728\u6bc5. \u6db2\u6ef4\u7834\u7815\u3092\u4f34\u3046\u5674\u9727\u4e7e\u71e5\u6cd5\u306b\u3088\u308b\u30ca\u30ce\u7c92\u5b50\u306e\u30a8\u30a2\u30ed\u30be\u30eb\u5316. \u7b2c30\u56de\u30a8\u30a2\u30ed\u30be\u30eb\u79d1\u5b66\u30fb\u6280\u8853\u8a0e\u8ad6\u4f1a. C02. (\u4eac\u90fd, 2013\u5e748\u670827\u65e5\uff5e29\u65e5).<\/p>\n<h5 id=\"2d\">\u2461(d) \u30a8\u30a2\u30ed\u30be\u30eb\u306e\u6db2\u76f8\u6355\u96c6\u624b\u6cd5\u306e\u69cb\u7bc9<\/h5>\n<p>\u5b9f\u65bd\u6a5f\u95a2\uff1a\u7523\u696d\u6280\u8853\u7dcf\u5408\u7814\u7a76\u6240 \u7269\u8cea\u8a08\u6e2c\u6a19\u6e96\u7814\u7a76\u90e8\u9580\u53ca\u3073\u8a08\u91cf\u6a19\u6e96\u666e\u53ca\u30bb\u30f3\u30bf\u30fc<\/p>\n<p>Iida K, Sakurai H, Ehara K (2013). Aerosol-to-Liquid Phase Collection: A Method for Making Liquid Suspension Containing Dry-Dispersed Nanomaterials. American Association for Aerosol Research 33nd Annual Conference. 3AE.2. (Florida, USA, October 20-24, 2014).<\/p>\n<p>Iida K, Sakurai H, Ehara K (2014). Aerosol-to-Liquid Phase Collection: A Method for Making Liquid Suspension Containing Dry-Dispersed Nanomaterials. International Aerosol Conference. SS07-4. (Busan, Korea, August 28-September 2, 2014).<\/p>\n<h3>\u2462\u3000\u30ca\u30ce\u6750\u6599\u306e\u6709\u5bb3\u6027\u8a66\u9a13\u30fb\u8a55\u4fa1\u306e\u305f\u3081\u306e\u57fa\u76e4\u6280\u8853\u306e\u958b\u767a<\/h3>\n<h5 id=\"3a-1\">\u2462(a-1) \u30ca\u30ce\u6750\u6599\u306e\u4f53\u5185\u5206\u5e03\u53ca\u3073\u751f\u4f53\u53cd\u5fdc\u5206\u5e03\u306e\u5b9a\u91cf\u5316\u6280\u8853\u306e\u958b\u767a<\/h5>\n<p>\u5b9f\u65bd\u6a5f\u95a2\uff1a\u7523\u696d\u6280\u8853\u7dcf\u5408\u7814\u7a76\u6240 \u5206\u6790\u8a08\u6e2c\u6a19\u6e96\u7814\u7a76\u90e8\u9580<\/p>\n<p>Horie M., Komaba K., Kato H., Endo S., Fujita K., Nishio K., Nakamura A., Yamamoto K., Kinugasa S., Hagiwara Y., Yoshida Y., Iwahashi H., \u00a0Cellular effects of industrial metal nanoparticles and hydrophilic carbon black dispersion, JOURNAL OF TOXICOLOGICAL SCIENCES, 39, 6(2014)897-907.<\/p>\n<h5 id=\"3a-2\">\u2462(a-2) PEAPOD\u306e\u4f53\u5185\u52d5\u614b\u8a08\u6e2c\u6280\u8853\u958b\u767a<\/h5>\n<p>\u5b9f\u65bd\u6a5f\u95a2\uff1a\u4fe1\u5dde\u5927\u5b66<\/p>\n<p>Tsuruoka S,\u3000Matsumoto H, Castranovai V Porter, D.W, Yanagisawa T, Saito N, Kobayashi S, Endo M. Differential of chemical reaction activity of various carbon nanotubes using redox potential : Classification by physical and chemical structures. Carbon 95, 302-308 (2015).<\/p>\n<p>Tsuruoka S, Matsumoto H, Koyama K, Akiba E, Yanagisawa T, Flemming R. C, Saito N, Usui Y, Kobayashi S, Dale W. P, Vinsent C, Endo M (2015). Radical scavenging reaction kinetics with multiwalled carbon nanotubes. Carbon. 83, 232-239.<\/p>\n<p>Kobayashi S, Tsuruoka S, Usui Y, Haniu H, Aoki K, Takanashi S, Okamoto M, Nomura H, Tanaka M, Aiso S, Saito M, Kato H, Saito N (2015). An advanced in-situ imaging method using heavy metal doped hollow tubes to evaluate the biokinetics of carbon nanotubes in vivo, NPG Asia Materials 7, e203, 2015.<\/p>\n<p>\u4fe1\u5dde\u5927\u5b66, \u682a\u5f0f\u4f1a\u793e\u30ea\u30ac\u30af. \u70ad\u7d20\u7c92\u5b50\u306e\u7a7a\u9593\u5206\u5e03\u540c\u5b9a\u65b9\u6cd5. \u7279\u958b2015-99123. 2015-05-28.<\/p>\n<h5 id=\"3b\">\u2462(b) \u30ca\u30ce\u6750\u6599\u306e\u4f53\u5185\u52d5\u614b\u3068\u751f\u4f53\u53cd\u5fdc\u306b\u95a2\u3059\u308b\u6570\u7406\u30e2\u30c7\u30eb\u306e\u69cb\u7bc9<\/h5>\n<p>\u5b9f\u65bd\u6a5f\u95a2\uff1a\u7523\u696d\u6280\u8853\u7dcf\u5408\u7814\u7a76\u6240 \u5b89\u5168\u79d1\u5b66\u7814\u7a76\u90e8\u9580<\/p>\n<p>Zhang G, Shinohara N, Kano H, Senoh H, Suzuki M, Sasaki T, Fukushima S, Gamo M (2016). Quantitative evaluation of local pulmonary distribution of TiO<sub>2<\/sub> in rats following single or multiple intratracheal administrations of TiO<sub>2<\/sub> nanoparticles using X-ray fluorescence microscopy. Journal of Applied Toxicology, DOI:10.1002\/jat.3287.<\/p>\n<p>Zhang G, Shinohara N, Kano H, Senoh H, Suzuki M, Sasaki T, Fukushima S, Gamo M (2015). Quantitative evaluation of the pulmonary microdistribution of TiO<sub>2<\/sub> nanoparticles using XRF microscopy after intratracheal administration with a microsprayer in rats. Journal of Applied Toxicology, 35:623-630, DOI:10.1002\/jat.3109.<\/p>\n<p>Shinohara N, Oshima Y, Kobayashi T, Imatanaka N, Nakai M, Ichinose T, Sasaki T, Kawaguchi K, Zhang G, Gamo M (2015). Pulmonary clearance kinetics and extrapulmonary translocation of seven titanium dioxide nano and submicron materials following intratracheal administration in rats. Nanotoxicology, 9:1050-1058, DOI:10.3109\/17435390.2015.1015644.<\/p>\n<p>Shinohara\u3000N, Oshima Y, Kobayashi T, Imatanaka N, Nakai M, Ichinose T, Sasaki T, Zhang G, Fukui H, Gamo M (2014). Dose-dependent clearance kinetics of intratracheally administered titanium dioxide nanoparticles in rat lung. Toxicology, 325:1-11, DOI:10.1016\/j.tox.2014.08.003.<\/p>\n<p>Shinohara N, Danno N, Ichinose T, Sasaki T, Fukui H, Honda K, Gamo M (2014). Tissue distribution and clearance of intravenously administered titanium dioxide (TiO<sub>2<\/sub>) nanoparticles, Nanotoxicology, 8:132-141, DOI: 10.3109\/17435390.2012.763001.<\/p>\n<p>Ema M, Gamo M, Honda K. (2016) A review of toxicity studies of single-walled carbon nanotubes in laboratory animals. Regul Toxicol Pharmacol. 74, 42-63.<\/p>\n<p>Ema M, Hougaard KS, Kishimoto A, Honda K. (2016) Reproductive and developmental toxicity of carbon-based nanomaterials: A literature review. Nanotoxicology 10, 391-412.<\/p>\n<p>Ema M, Gamo M, Honda K. (2016) Developmental toxicity of engineered nanomaterials in rodents. Toxicol Appl Pharmacol 299, 47-52.<\/p>\n<p>\u6c5f\u99ac\u3000\u771e (2015)\u3001\u30ca\u30ce\u30de\u30c6\u30ea\u30a2\u30eb\u306e\u5065\u5eb7\u5f71\u97ff\u8a55\u4fa1\u3001\u81ea\u52d5\u8eca\u6280\u8853\u300169(11), 16-21.<\/p>\n<h5 id=\"3c\">\u2462(c) \u57f9\u990a\u80ba\u80de\u30e2\u30c7\u30eb\u8a55\u4fa1\u7cfb\u306e\u958b\u767a\u3068\u6570\u7406\u30e2\u30c7\u30eb\u5316\u3078\u306e\u5229\u7528\u65b9\u6cd5\u306b\u95a2\u3059\u308b\u7814\u7a76\u958b\u767a<\/h5>\n<p>\u5b9f\u65bd\u6a5f\u95a2\uff1a\u6771\u4eac\u5927\u5b66 \u751f\u7523\u6280\u8853\u7814\u7a76\u6240<\/p>\n<p>Iwasawa K, Tanaka G, Aoyama T, Chowdhury MM, Shinohara M, Komori K, Tanaka-Kagawa T, Jinno H, Sakai Y (2013). Prediction of phthalate permeation through pulmonary alveoli using a cultured A549 cell-based in vitro alveolus model and a numerical simulation. AATEX. 18(1), 19-31.<\/p>\n<p>\u5ca9\u6ca2 \u3053\u3053\u308d, \u9152\u4e95 \u5eb7\u884c (2013). \u57f9\u990a\u80ba\u80de\u30e2\u30c7\u30eb\u8a55\u4fa1\u7cfb\u306e\u958b\u767a\u3068\u6570\u7406\u30e2\u30c7\u30eb\u5316. In vitro \u6bd2\u6027\u30fb\u52d5\u614b\u8a55\u4fa1\u306e\u6700\u524d\u7dda\uff08\u30b7\u30fc\u30a8\u30e0\u30b7\u30fc\u51fa\u7248\uff09 \u7b2c5\u7de8, \u7b2c2\u7ae0, pp. 153-158\uff0e<\/p>\n<p>\u9152\u4e95 \u5eb7\u884c, \u5c0f\u68ee \u559c\u4e45\u592b (2011). \u30d2\u30c8\u30cf\u30b6\u30fc\u30c9\u8a55\u4fa1\u306b\u304a\u3051\u308b\u65b0\u3057\u3044\u6d41\u308c\u3068\u8ab2\u984c. \u81ea\u52d5\u8eca\u7814\u7a76. 33(5), 9-14.<\/p>\n<h3 id=\"4\">\u2463\u3000\u56fd\u969b\u52d5\u5411\u306e\u628a\u63e1<\/h3>\n<p>\u5b9f\u65bd\u6a5f\u95a2\uff1a\u7523\u696d\u6280\u8853\u7dcf\u5408\u7814\u7a76\u6240 \u5b89\u5168\u79d1\u5b66\u7814\u7a76\u90e8\u9580 \u53ca\u3073 \u6176\u61c9\u7fa9\u587e\u5927\u5b66 \u533b\u5b66\u90e8<\/p>\n<p>Masashi Gamo (2016). Development of Equivalence Criteria for Nanomaterials by Intratracheal Administration. <a href=\"http:\/\/www.oecd.org\/officialdocuments\/publicdisplaydocumentpdf\/?cote=ENV\/JM\/MONO(2016)9&amp;docLanguage=En\" target=\"_blank\">Categorisation of manufactured nanomaterials &#8212; Workshop report. OECD. Series on the Safety of Manufactured Nanomaterials No.66<\/a>, ENV\/JM\/MONO(2016)9,65-66.<\/p>\n<p>Takuya Igarashi (2016). Approaches to Develop or Use Concepts of Grouping, Equivalence and Read-Across Based on Physical-Chemical Properties (GERA-PC) of Nanomaterials for their Hazard Assessment in Regulatory Regimes. <a href=\"http:\/\/www.oecd.org\/officialdocuments\/publicdisplaydocumentpdf\/?cote=ENV\/JM\/MONO(2016)9&amp;docLanguage=En\" target=\"_blank\">Categorisation of manufactured nanomaterials &#8212; Workshop report. OECD. Series on the Safety of Manufactured Nanomaterials No.66<\/a>, ENV\/JM\/MONO(2016)9,18-19.<\/p>\n<p>Takuya Igarashi (2016). <a href=\"http:\/\/www.oecd.org\/officialdocuments\/publicdisplaydocumentpdf\/?cote=ENV\/JM\/MONO(2016)3&amp;docLanguage=En\" target=\"_blank\">Approaches on nano grouping\/equivalence\/read-across concepts based on physical- chemical properties (GERA-PC) for regulatory regimes &#8212; Results from the Survey. OECD. Series on the Safety of Manufactured Nanomaterials No.64<\/a>, ENV\/JM\/MONO(2016)3.<\/p>\n<p>\u4e94\u5341\u5d50 \u5353\u4e5f (2015). \u7279\u96c6 \u30ca\u30ce\u30de\u30c6\u30ea\u30a2\u30eb\u3068\u30ca\u30ce\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\uff1a \u30ca\u30ce\u30de\u30c6\u30ea\u30a2\u30eb\u306e\u5b89\u5168\u6027\u306b\u95a2\u3059\u308b\u898f\u5236\u306e\u56fd\u969b\u52d5\u5411. \u81ea\u52d5\u8eca\u6280\u8853. 69(11), 11-15.<\/p>\n<p>\u4e94\u5341\u5d50 \u5353\u4e5f (2013). \u7b2c10\u7ae0 \u7c89\u4f53\u306b\u95a2\u3059\u308b\u898f\u5236\u3068\u305d\u306e\u5bfe\u5fdc\u5b9f\u52d9 \u7b2c1\u7bc0 \u30ca\u30ce\u30de\u30c6\u30ea\u30a2\u30eb\u306e\u30ea\u30b9\u30af\u3068\u5b89\u5168\u6027\u8a55\u4fa1. \u7c89\uff65\u7c92\u4f53\u306e\u69cb\u9020\u5236\u5fa1, \u8868\u9762\u51e6\u7406\u3068\u30d7\u30ed\u30bb\u30b9\u8a2d\u8a08. \u6280\u8853\u60c5\u5831\u5354\u4f1a. 833-845.<\/p>\n<p>\u4e94\u5341\u5d50 \u5353\u4e5f (2013). 8 \u5b89\u5168\u6027\u306b\u95a2\u3059\u308b\u898f\u5236\u306e\u52d5\u5411. \u6700\u65b0 \u30ca\u30ce\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u306e\u56fd\u969b\u6a19\u6e96\u5316 \u2015 \u5e02\u5834\u5c55\u958b\u304b\u3089\u898f\u5236\u52d5\u5411\u307e\u3067. \u65e5\u672c\u898f\u683c\u5354\u4f1a. 159-184.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u2460\u3000\u30ca\u30ce\u6750\u6599\u306e\u540c\u7b49\u6027\u5224\u65ad\u306e\u305f\u3081\u306e\u8a55\u4fa1\u6280\u8853\u306e\u69cb\u7bc9 \u2460(a) \u6c17\u7ba1\u5185\u6295\u4e0e\u8a66\u9a13\u306b\u3088\u308b\u30ca\u30ce\u6750\u6599\u306e\u76f8\u4e92\u6bd4\u8f03\u306b\u3088\u308b\u540c\u7b49\u6027\u5224\u65ad\u57fa\u6e96\u306e\u69cb\u7bc9 \u5b9f\u65bd\u6a5f\u95a2\uff1a\u5316\u5b66\u7269\u8cea\u8a55\u4fa1\u7814\u7a76\u6a5f\u69cb Hashizume N, Oshima Y, Nakai M,  [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":23,"comment_status":"open","ping_status":"open","template":"","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":"","_links_to":"","_links_to_target":""},"tags":[],"class_list":["post-190","page","type-page","status-publish","hentry"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 4.9.8 - 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