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\u7523\u7dcf\u7814\u306e\u7814\u7a76\u6210\u679c\u3068\u3057\u3066\u3001\u201d Pulmonary inflammatory responses and retention dynamics of cellulose nanofibrils\u201d\u3068\u984c\u3057\u305f\u7814\u7a76\u8ad6\u6587\u304c\u3001Toxicology\uff08Elsevier\uff09\u306b\u304a\u3044\u30662024\u5e7412\u670822\u65e5\u4ed8\u3051\u3067\u767a\u884c\u3055\u308c\u307e\u3057\u305f\u3002
\u30bb\u30eb\u30ed\u30fc\u30b9\u30ca\u30ce\u30d5\u30a1\u30a4\u30d0\u30fc\uff08CNF\uff09\u306f\u3001\u30d0\u30a4\u30aa\u30de\u30b9\u7531\u6765\u306e\u8efd\u91cf\u304b\u3064\u9ad8\u5f37\u5ea6\u306a\u7d20\u6750\u3067\u3042\u308a\u3001\u77f3\u6cb9\u7531\u6765\u7d20\u6750\u306e\u4ee3\u66ff\u3068\u3057\u3066\u671f\u5f85\u3055\u308c\u308b\u6709\u671b\u306a\u6750\u6599\u3067\u3059\u3002\u672c\u7a3f\u3067\u306f\u3001CNF\u88fd\u54c1\u306e\u5b89\u5168\u6027\u8a55\u4fa1\u3092\u76ee\u7684\u3068\u3057\u3066\u30e9\u30c3\u30c8\u3092\u7528\u3044\u305f\u52d5\u7269\u8a66\u9a13\u3092\u5b9f\u65bd\u3057\u3001\u305d\u306e\u7d50\u679c\u3092\u57fa\u306bCNF\u66b4\u9732\u306b\u3088\u308b\u6f5c\u5728\u7684\u306a\u5438\u5165\u5f71\u97ff\u306b\u3064\u3044\u3066\u8003\u5bdf\u3057\u307e\u3057\u305f\u3002<\/p>\n

\u672c\u7814\u7a76\u3067\u306f\u3001\u30e9\u30c3\u30c8\u3092\u7528\u3044\u3066CNF\u306e\u6c17\u7ba1\u5185\u6295\u4e0e\u5f8c\u306b\u304a\u3051\u308b\u80ba\u708e\u75c7\u53cd\u5fdc\u304a\u3088\u3073\u7d44\u7e54\u5185\u6b8b\u7559\u3092\u8a55\u4fa1\u3057\u307e\u3057\u305f\u3002\u4f7f\u7528\u3057\u305fCNF\u306f\u3001\u7269\u7406\u7684\u7279\u6027\u306e\u7570\u306a\u308bTEMPO\u9178\u5316CNF\u3001\u6a5f\u68b0\u7684\u89e3\u7e4aCNF\u3001\u77ed\u7e4a\u7dadCNF\u306e3\u7a2e\u985e\u3067\u3001\u305d\u308c\u305e\u308c\u30e9\u30c3\u30c8\u4f53\u91cd1 kg\u3042\u305f\u308a2.0 mg\u306e\u7528\u91cf\u3067\u6295\u4e0e\u3057\u307e\u3057\u305f\u3002\u80ba\u708e\u75c7\u306e\u8a55\u4fa1\u306f\u6295\u4e0e28\u65e5\u5f8c\u306b\u5b9f\u65bd\u3057\u3001\u5316\u5b66\u67d3\u8272\u3057\u305fCNF\u306e\u80ba\u5185\u6b8b\u7559\u306f90\u65e5\u9593\u8ffd\u8de1\u3057\u307e\u3057\u305f\u3002
\u305d\u306e\u7d50\u679c\u3001\u4ee5\u4e0b\u306e\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002(1) CNF\u306f\u80ba\u80de\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306b\u53d6\u308a\u8fbc\u307e\u308c\u307e\u3057\u305f\u304c\u3001\u9855\u8457\u306a\u6025\u6027\u708e\u75c7\u306f\u89b3\u5bdf\u3055\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002(2) CNF\u306e\u7269\u7406\u7684\u7279\u6027\u3001\u7279\u306b\u7e4a\u7dad\u5f84\u3068\u9577\u3055\u304c\u3001\u80ba\u708e\u75c7\u306e\u7a0b\u5ea6\u3084\u708e\u75c7\u90e8\u4f4d\u306b\u5927\u304d\u304f\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3057\u305f\u3002(3) CNF\u61f8\u6fc1\u6db2\u4e2d\u306e\u30a8\u30f3\u30c9\u30c8\u30ad\u30b7\u30f3\u6fc3\u5ea6\u306f\u3001\u708e\u75c7\u53cd\u5fdc\u306b\u5bfe\u3057\u3066\u9650\u5b9a\u7684\u306a\u5f71\u97ff\u3057\u304b\u53ca\u307c\u3055\u306a\u3044\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002(4) CNF\u306f\u80ba\u7d44\u7e54\u5185\u306b\u9577\u671f\u9593\u6b8b\u7559\u3057\u3001\u7de9\u3084\u304b\u306a\u30af\u30ea\u30a2\u30e9\u30f3\u30b9\u3092\u793a\u3057\u307e\u3057\u305f\u3002
\u3053\u308c\u3089\u306e\u7d50\u679c\u304b\u3089\u3001CNF\u306f\u6025\u6027\u708e\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u4f4e\u3044\u4e00\u65b9\u3067\u3001\u80ba\u5185\u3067\u306e\u9577\u671f\u7684\u306a\u6b8b\u7559\u304c\u6162\u6027\u7684\u306a\u4f4e\u30ec\u30d9\u30eb\u306e\u708e\u75c7\u3092\u8a98\u767a\u3059\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u307e\u3059\u3002\u307e\u305f\u3001CNF\u306e\u7279\u6027\u306f\u539f\u6599\u4f9b\u7d66\u6e90\u3084\u88fd\u9020\u5de5\u7a0b\u306b\u3088\u308a\u5927\u304d\u304f\u7570\u306a\u308b\u305f\u3081\u3001\u5404CNF\u306e\u5b89\u5168\u6027\u3092\u500b\u5225\u306b\u8a55\u4fa1\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u4eca\u5f8c\u306f\u708e\u75c7\u4ee5\u5916\u306e\u6bd2\u6027\u8a55\u4fa1\u3082\u542b\u3081\u305f\u5305\u62ec\u7684\u306a\u691c\u8a0e\u304c\u91cd\u8981\u3067\u3042\u308b\u3068\u8003\u3048\u307e\u3059\u3002<\/p>\n

\"\"<\/p>\n

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\u30ea\u30f3\u30af
https:\/\/doi.org\/10.1016\/j.tox.2024.154038<\/a>
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\uff08\u6587\u8cac\uff1a\u85e4\u7530\u514b\u82f1\uff09<\/p>\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

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