{"id":2000,"date":"2025-10-01T09:26:00","date_gmt":"2025-10-01T00:26:00","guid":{"rendered":"https:\/\/riss.aist.go.jp\/nanosafety\/?p=2000"},"modified":"2025-10-04T22:54:19","modified_gmt":"2025-10-04T13:54:19","slug":"crtox2025","status":"publish","type":"post","link":"https:\/\/riss.aist.go.jp\/nanosafety\/2025\/10\/01\/crtox2025\/","title":{"rendered":"2025\u5e7410\u6708 \u3010\u8ad6\u6587\u3011\u30ca\u30ce\u30bb\u30eb\u30ed\u30fc\u30b9\u306e\u80ba\u6bd2\u6027\u3068\u514d\u75ab\u5fdc\u7b54\u306b\u3064\u3044\u3066\u306e\u7814\u7a76\u8ad6\u6587"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">\uff082025\u5e7410\u67081\u65e5\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7523\u7dcf\u7814\u306e\u7814\u7a76\u6210\u679c\u3068\u3057\u3066\u3001\u201cPulmonary inflammation and immune responses induced by nanocellulose: Insights from <em>in vivo<\/em> and <em>in vitro<\/em> models\u201d\u3068\u984c\u3057\u305f\u7814\u7a76\u8ad6\u6587\u304c\u3001Current Research in Toxicology\uff08Elsevier\uff09\u306b\u304a\u3044\u30662025\u5e749\u670825\u65e5\u4ed8\u3051\u3067\u767a\u884c\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30bb\u30eb\u30ed\u30fc\u30b9\u30ca\u30ce\u30d5\u30a1\u30a4\u30d0\u30fc\uff08CNF\uff09\u304a\u3088\u3073\u30bb\u30eb\u30ed\u30fc\u30b9\u30ca\u30ce\u30af\u30ea\u30b9\u30bf\u30eb\uff08CNC\uff09\u306a\u3069\u306e\u30ca\u30ce\u30bb\u30eb\u30ed\u30fc\u30b9\uff08NC\uff09\u306f\u3001\u5316\u7ca7\u54c1\u3001\u98df\u54c1\u3001\u5efa\u6750\u30fb\u4f4f\u5b85\u3001\u5305\u88c5\u6750\u3001\u533b\u7642\u88fd\u54c1\u306a\u3069\u3001\u5e45\u5e83\u3044\u5206\u91ce\u3067\u306e\u5fdc\u7528\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u547c\u5438\u53ef\u80fd\u7c92\u5b50\u30b5\u30a4\u30ba\uff08&lt;10 \u00b5m\uff09\u3092\u542b\u3080\u305f\u3081\u3001\u5438\u5165\u66dd\u9732\u306b\u3088\u308b\u5065\u5eb7\u5f71\u97ff\u304c\u61f8\u5ff5\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u672c\u7814\u7a76\u3067\u306f\u3001TEMPO\u9178\u5316CNF\uff08CNF1\uff09\u3001\u6a5f\u68b0\u7684\u89e3\u7e4aCNF\uff08CNF2\uff09\u3001CNC1\u3092\u7528\u3044\u3066\u3001\u30e9\u30c3\u30c8\u3078\u306e\u6c17\u7ba1\u5185\u6295\u4e0e\u306b\u3088\u308b\u80ba\u6bd2\u6027\u3068\u514d\u75ab\u6bd2\u6027\u3092\u8a55\u4fa1\u3057\u3001\u6bd4\u8f03\u5bfe\u8c61\u3068\u3057\u3066\u591a\u5c64\u30ab\u30fc\u30dc\u30f3\u30ca\u30ce\u30c1\u30e5\u30fc\u30d6\uff08MWCNT\uff09\u3082\u4f7f\u7528\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3059\u3079\u3066\u306e\u6750\u6599\u306f2.0 mg\/kg\u3067\u6295\u4e0e\u3055\u308c\u300128\u65e5\u5f8c\u306b\u306f\u5168\u3066\u306eNC\u304c\u80ba\u80de\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306b\u8caa\u98df\u3055\u308c\u307e\u3057\u305f\u3002CNF1\u3068CNC1\u306f\u708e\u75c7\u6027\u30de\u30fc\u30ab\u30fc\u306b\u5909\u5316\u3092\u793a\u3057\u3001CNC1\u306f\u6700\u3082\u9855\u8457\u306a\u7d44\u7e54\u5909\u5316\u3092\u793a\u3057\u307e\u3057\u305f\u3002CNF2\u306f\u9650\u5c40\u7684\u306a\u708e\u75c7\u3068\u8089\u82bd\u816b\u5f62\u6210\u3092\u793a\u3057\u3001BALF\u306e\u5909\u5316\u306f\u6700\u5c0f\u9650\u3067\u3057\u305f\u3002\u3044\u305a\u308c\u306eNC\u3082MWCNT\u3088\u308a\u708e\u75c7\u53cd\u5fdc\u304a\u3088\u3073\u7d44\u7e54\u5909\u5316\u304c\u8efd\u5ea6\u3067\u3057\u305f\u3002\u813e\u81d3\u30fb\u80f8\u817a\u306e\u30ea\u30f3\u30d1\u7403\u30b5\u30d6\u30bb\u30c3\u30c8\u306b\u6709\u610f\u306a\u5909\u5316\u306f\u8a8d\u3081\u3089\u308c\u305a\u3001\u5168\u8eab\u6027\u514d\u75ab\u6bd2\u6027\u306f\u78ba\u8a8d\u3055\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em>in vitro<\/em>\u8a66\u9a13\u3067\u306f\u3001CNC1\u3001CNC2\uff08\u786b\u9178\u52a0\u6c34\u5206\u89e3\uff09\u3001CNC3\uff08\u8131\u786b\uff09\u3092\u6bd4\u8f03\u3057\u305f\u7d50\u679c\u3001\u5168\u3066\u306eCNC\u304c\u30e9\u30c3\u30c8\u80ba\u80de\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\uff08NR8383\uff09\u306b\u53d6\u308a\u8fbc\u307e\u308c\u3001\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u7523\u751f\u304c\u5897\u52a0\u3057\u307e\u3057\u305f\u3002\u53cd\u5fdc\u306f\u8868\u9762\u5316\u5b66\u306b\u3088\u308a\u7570\u306a\u308a\u3001CNC3\u306f\u8efd\u5ea6\u301c\u4e2d\u7b49\u5ea6\u306e\u7d30\u80de\u6bd2\u6027\u3092\u793a\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u308c\u3089\u306e\u7d50\u679c\u304b\u3089\u3001NC\u306f\u4e00\u822c\u306bMWCNT\u3088\u308a\u3082\u80ba\u6bd2\u6027\u304c\u4f4e\u3044\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u304c\u3001\u305d\u306e\u751f\u7269\u5b66\u7684\u5f71\u97ff\u306f\u7e4a\u7dad\u5f62\u614b\u3001\u8868\u9762\u7279\u6027\u3001\u80ba\u5185\u3067\u306e\u6c88\u7740\u6319\u52d5\u306b\u3088\u308a\u5927\u304d\u304f\u5de6\u53f3\u3055\u308c\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\u3002NC\u306e\u5b89\u5168\u306a\u5229\u7528\u306b\u306f\u3001\u6df7\u5165\u5fae\u751f\u7269\u3084\u30a8\u30f3\u30c9\u30c8\u30ad\u30b7\u30f3\u306e\u53b3\u5bc6\u306a\u691c\u67fb\u3068\u7ba1\u7406\u3092\u542b\u3081\u3001\u6750\u6599\u7279\u6027\u306b\u5fdc\u3058\u305f\u5305\u62ec\u7684\u306a\u6bd2\u6027\u8a55\u4fa1\u3068\u6a19\u6e96\u5316\u3055\u308c\u305f\u8a55\u4fa1\u67a0\u7d44\u307f\u304c\u4e0d\u53ef\u6b20\u3067\u3059\u3002<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><a href=\"https:\/\/riss.aist.go.jp\/nanosafety\/wp-content\/uploads\/sites\/10\/2025\/10\/image.png\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"535\" src=\"https:\/\/riss.aist.go.jp\/nanosafety\/wp-content\/uploads\/sites\/10\/2025\/10\/image-1024x535.png\" alt=\"\" class=\"wp-image-2024\" style=\"width:674px;height:auto\" srcset=\"https:\/\/riss.aist.go.jp\/nanosafety\/wp-content\/uploads\/sites\/10\/2025\/10\/image-1024x535.png 1024w, https:\/\/riss.aist.go.jp\/nanosafety\/wp-content\/uploads\/sites\/10\/2025\/10\/image-300x157.png 300w, https:\/\/riss.aist.go.jp\/nanosafety\/wp-content\/uploads\/sites\/10\/2025\/10\/image-768x401.png 768w, https:\/\/riss.aist.go.jp\/nanosafety\/wp-content\/uploads\/sites\/10\/2025\/10\/image.png 1160w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u672c\u7814\u7a76\u306f\u3001\u56fd\u7acb\u7814\u7a76\u958b\u767a\u6cd5\u4eba\u65b0\u30a8\u30cd\u30eb\u30ae\u30fc\u30fb\u7523\u696d\u6280\u8853\u7dcf\u5408\u958b\u767a\u6a5f\u69cb\uff08NEDO\uff09\u306e\u59d4\u8a17\u696d\u52d9\u300c\u70ad\u7d20\u5faa\u74b0\u793e\u4f1a\u306b\u8ca2\u732e\u3059\u308b\u30bb\u30eb\u30ed\u30fc\u30b9\u30ca\u30ce\u30d5\u30a1\u30a4\u30d0\u30fc\u95a2\u9023\u6280\u8853\u958b\u767a\uff0fCNF\u5229\u7528\u6280\u8853\u306e\u958b\u767a\uff0f\u591a\u69d8\u306a\u88fd\u54c1\u7528\u9014\u306b\u5bfe\u5fdc\u3057\u305f\u6709\u5bb3\u6027\u8a55\u4fa1\u624b\u6cd5\u306e\u958b\u767a\u3068\u5b89\u5168\u6027\u8a55\u4fa1\u300d\u306e\u7d50\u679c\u304b\u3089\u5f97\u3089\u308c\u305f\u3082\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30ea\u30f3\u30af<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/doi.org\/10.1016\/j.crtox.2025.100259\" target=\"_blank\" rel=\"noopener\" title=\"\">https:\/\/doi.org\/10.1016\/j.crtox.2025.100259<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30aa\u30fc\u30d7\u30f3\u30a2\u30af\u30bb\u30b9\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u306e\u3067\u3001\u5168\u6587\u3092\u7121\u511f\u3067\u95b2\u89a7\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uff08\u6587\u8cac\uff1a\u85e4\u7530\u514b\u82f1\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\uff082025\u5e7410\u67081\u65e5\uff09 \u7523\u7dcf\u7814\u306e\u7814\u7a76\u6210\u679c\u3068\u3057\u3066\u3001\u201cPulmonary inflammation and immune responses induced by nanocellulose: Insights from  [&hellip;]<\/p>\n","protected":false},"author":19,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[7,2],"tags":[],"class_list":["post-2000","post","type-post","status-publish","format-standard","hentry","category-cnf","category-news"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 4.9.10 - aioseo.com -->\n\t<meta name=\"description\" content=\"\uff082025\u5e7410\u67081\u65e5\uff09 \u7523\u7dcf\u7814\u306e\u7814\u7a76\u6210\u679c\u3068\u3057\u3066\u3001\u201cPulmonary inflammation and im\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<meta name=\"author\" content=\"fujita\"\/>\n\t<link rel=\"canonical\" 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