{"id":2135,"date":"2026-05-20T14:16:23","date_gmt":"2026-05-20T05:16:23","guid":{"rendered":"https:\/\/riss.aist.go.jp\/nanosafety\/?p=2135"},"modified":"2026-05-26T16:22:19","modified_gmt":"2026-05-26T07:22:19","slug":"cnf2026","status":"publish","type":"post","link":"https:\/\/riss.aist.go.jp\/nanosafety\/2026\/05\/20\/cnf2026\/","title":{"rendered":"2026\u5e745\u6708\u3000\u3010\u89e3\u8aac\u3011\u30ca\u30ce\u30bb\u30eb\u30ed\u30fc\u30b9\u5438\u5165\u6bd2\u6027\u3092\u3081\u3050\u308b\u77e5\u898b\uff1a\u81e8\u5e8a\u75c7\u4f8b\u3068\u7e4a\u7dad\u6b8b\u7559\u6027\u306e\u8996\u70b9\u304b\u3089"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">\uff082026\u5e745\u670820\u65e5\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30bb\u30eb\u30ed\u30fc\u30b9\u304a\u3088\u3073\u30ca\u30ce\u30bb\u30eb\u30ed\u30fc\u30b9\u306f\u3001\u4e00\u822c\u306b\u751f\u4f53\u9069\u5408\u6027\u304c\u9ad8\u304f\u3001\u6bd4\u8f03\u7684\u5b89\u5168\u306a\u6750\u6599\u3068\u3057\u3066\u5e83\u304f\u8a8d\u8b58\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u98df\u54c1\u3001\u533b\u85ac\u3001\u5316\u7ca7\u54c1\u3001\u6a5f\u80fd\u6750\u6599\u306a\u3069\u591a\u69d8\u306a\u7528\u9014\u3067\u5229\u7528\u3055\u308c\u3066\u304a\u308a\u3001\u5316\u5b66\u7684\u306b\u3082\u5b89\u5b9a\u3067\u6bd2\u6027\u304c\u4f4e\u3044\u6750\u6599\u3068\u8003\u3048\u3089\u308c\u3066\u304d\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e00\u65b9\u3067\u3001\u5438\u5165\u6bd2\u6027\u306e\u89b3\u70b9\u3067\u306f\u3001\u5f71\u97ff\u306f\u5316\u5b66\u7d44\u6210\u3060\u3051\u3067\u306a\u304f\u3001\u7e4a\u7dad\u5f84\u3001\u7e4a\u7dad\u9577\u3001\u51dd\u96c6\u72b6\u614b\u3001\u525b\u76f4\u6027\u3001\u80ba\u5185\u6b8b\u7559\u6027\uff08biopersistence\uff09\u306a\u3069\u306e\u7269\u7406\u7279\u6027\u306b\u5f37\u304f\u4f9d\u5b58\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u8fd1\u5e74\u3067\u306f\u3001\u30ca\u30ce\u30bb\u30eb\u30ed\u30fc\u30b9\u306b\u3064\u3044\u3066\u3082\u5438\u5165\u66dd\u9732\u6642\u306e\u708e\u75c7\u53cd\u5fdc\u3084\u6b8b\u7559\u6319\u52d5\u306b\u95a2\u3059\u308b\u7814\u7a76\u304c\u84c4\u7a4d\u3055\u308c\u3064\u3064\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u672c\u7a3f\u3067\u306f\u3001\u7dbf\u30fb\u30bb\u30eb\u30ed\u30fc\u30b9\u7e4a\u7dad\u5438\u5165\u306b\u3088\u308b\u80ba\u75c5\u5909\u3092\u5831\u544a\u3057\u305fKobayashi\u3089\u306e\u81e8\u5e8a\u75c7\u4f8b\u3092\u8d77\u70b9\u306b\u3001<strong>\u7dbf\u7c89\u3058\u3093\u80ba\uff08byssinosis\uff09<\/strong>\u3068\u306e\u9055\u3044\u3001\u3055\u3089\u306b\u8fd1\u5e74\u306e\u30ca\u30ce\u30bb\u30eb\u30ed\u30fc\u30b9\u5438\u5165\u6bd2\u6027\u7814\u7a76\u3068\u306e\u3064\u306a\u304c\u308a\u3092\u3001\u5b9f\u52d9\u7684\u89b3\u70b9\u304b\u3089\u6574\u7406\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u306a\u304a\u3001\u672c\u7a3f\u306f\u3001\u30ca\u30ce\u30bb\u30eb\u30ed\u30fc\u30b9\u3084\u7279\u5b9a\u6750\u6599\u306e\u30ea\u30b9\u30af\u3092\u5f37\u8abf\u3059\u308b\u3082\u306e\u3067\u306f\u306a\u304f\u3001\u65e2\u5b58\u77e5\u898b\u306b\u57fa\u3065\u304d\u5438\u5165\u5f71\u97ff\u306e\u7406\u89e3\u3092\u6574\u7406\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u305f\u3081\u3001\u500b\u5225\u6750\u6599\u306e\u5b89\u5168\u6027\u8a55\u4fa1\u3084\u898f\u5236\u5224\u65ad\u3092\u76f4\u63a5\u793a\u3059\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>1. \u4f4d\u7f6e\u3065\u3051<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u672c\u7a3f\u306e\u8981\u70b9\u306f\u3001\u30bb\u30eb\u30ed\u30fc\u30b9\u7cfb\u6750\u6599\u3067\u3042\u3063\u3066\u3082\u3001\u80ba\u5185\u306b\u6bd4\u8f03\u7684\u9577\u671f\u6b8b\u7559\u3057\u5f97\u308b\u7e4a\u7dad\u5f62\u614b\u3084\u51dd\u96c6\u72b6\u614b\u3092\u3068\u308b\u5834\u5408\u306b\u306f\u3001\u6162\u6027\u7684\u306a\u7570\u7269\u53cd\u5fdc\u3092\u751f\u3058\u5f97\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u3044\u3046\u70b9\u306b\u3042\u308a\u307e\u3059\u3002<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u308c\u3089\u306e\u77e5\u898b\u306f\u3001\u300c\u30bb\u30eb\u30ed\u30fc\u30b9\uff1d\u672c\u8cea\u7684\u306b\u5b89\u5168\u300d\u3068\u3044\u3046\u5358\u7d14\u306a\u56f3\u5f0f\u3067\u306f\u306a\u304f\u3001\u30bb\u30eb\u30ed\u30fc\u30b9\u7cfb\u6750\u6599\u3067\u3042\u3063\u3066\u3082\u3001\u7e4a\u7dad\u72b6\u5f62\u614b\u30fb\u6b8b\u7559\u6027\u30fb\u51dd\u96c6\u72b6\u614b\u306b\u3088\u3063\u3066\u306f\u6162\u6027\u7684\u306a\u7570\u7269\u53cd\u5fdc\u3092\u751f\u3058\u5f97\u308b\u53ef\u80fd\u6027\u3092\u793a\u5506\u3059\u308b\u3082\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305f\u3060\u3057\u3001\u73fe\u6642\u70b9\u3067\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u30d2\u30c8\u75c7\u4f8b\u306f\u6975\u3081\u3066\u9650\u5b9a\u7684\u3067\u3042\u308a\u3001\u30ca\u30ce\u30bb\u30eb\u30ed\u30fc\u30b9\u306e\u5438\u5165\u6bd2\u6027\u7814\u7a76\u3067\u3082\u3001\u591a\u304f\u306f\u8efd\u5ea6\u301c\u4e2d\u7b49\u5ea6\u708e\u75c7\u30ec\u30d9\u30eb\u306b\u7559\u307e\u3063\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/doi.org\/10.1016\/j.carpta.2025.100913\" target=\"_blank\" rel=\"noopener\" title=\"\">Fujita &amp; Moriyama, 2025<\/a>\uff09\u3002\u4e00\u65b9\u3001\u8fd1\u5e74\u306e\u767a\u3058\u3093\u6027\u7814\u7a76\u3067\u306f\u3001\u4e7e\u71e5\u30ca\u30ce\u30bb\u30eb\u30ed\u30fc\u30b9\u7c89\u4f53\u304b\u3089\u767a\u751f\u3059\u308b\u30a8\u30a2\u30ed\u30be\u30eb\u306f\u3001\u5b64\u7acb\u7e4a\u7dad\u3067\u306f\u306a\u304f\u3001\u4e3b\u3068\u3057\u3066\u51dd\u96c6\u30fb\u51dd\u584a\u7c92\u5b50\u3068\u3057\u3066\u5b58\u5728\u3059\u308b\u3053\u3068\u3082\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/doi.org\/10.1016\/j.impact.2025.100610\" target=\"_blank\" rel=\"noopener\" title=\"\">Ogura and Kotake, 2025<\/a>\uff09\u3002\u3053\u308c\u306f\u3001\u5b9f\u4f5c\u696d\u74b0\u5883\u306b\u304a\u3051\u308b\u66dd\u9732\u5f62\u614b\u304c\u3001\u6750\u6599\u305d\u306e\u3082\u306e\u306e\u4e00\u6b21\u69cb\u9020\u3068\u306f\u5fc5\u305a\u3057\u3082\u4e00\u81f4\u3057\u306a\u3044\u53ef\u80fd\u6027\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u73fe\u6642\u70b9\u3067\u306f\u3001\u30ca\u30ce\u30bb\u30eb\u30ed\u30fc\u30b9\u306b\u3064\u3044\u3066\u3001\u52d5\u7269\u8a66\u9a13\u306b\u304a\u3044\u3066\u4e2d\u76ae\u816b\u306e\u767a\u751f\u3084\u95a2\u9023\u3059\u308b\u708e\u75c7\u5fdc\u7b54\u3092\u793a\u3059\u660e\u78ba\u306a\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u305b\u3093\uff08<a href=\"https:\/\/doi.org\/10.1016\/j.impact.2025.100561\" target=\"_blank\" rel=\"noopener\" title=\"\">Horie et al., 2025<\/a>\uff09\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u91cd\u8981\u306a\u306e\u306f\u3001\u300c\u5316\u5b66\u7d44\u6210\u300d\u3060\u3051\u3067\u306a\u304f\u3001\u300c\u7e4a\u7dad\u3068\u3057\u3066\u306e\u7269\u7406\u7279\u6027\u300d\u3068\u300c\u80ba\u5185\u6b8b\u7559\u6027\u300d\u3092\u7d71\u5408\u7684\u306b\u8a55\u4fa1\u3059\u308b\u8996\u70b9\u3067\u3059\u3002<\/strong>\u7279\u306b\u3001\u9577\u7e4a\u7dad\u5316\u3001\u51dd\u96c6\u72b6\u614b\u3001\u80ba\u30af\u30ea\u30a2\u30e9\u30f3\u30b9\u7279\u6027\u306f\u3001\u4eca\u5f8c\u306e\u5438\u5165\u5b89\u5168\u6027\u8a55\u4fa1\u306b\u304a\u3051\u308b\u91cd\u8981\u306a\u8ad6\u70b9\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>1\uff09Kobayashi\u3089\u306e\u75c7\u4f8b\u306f\u300c\u5178\u578b\u7684byssinosis\u300d\u3068\u306f\u7570\u306a\u308b<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/doi.org\/10.1136\/thx.2003.014027\" target=\"_blank\" rel=\"noopener\" title=\"\">Kobayashi et al. (2004)<\/a>\u306f\u3001\u7d0450\u5e74\u9593\u306b\u308f\u305f\u308a\u7dbf\u7e4a\u7dad\u3078\u8077\u696d\u66dd\u9732\u3057\u305f66\u6b73\u7537\u6027\u306b\u304a\u3044\u3066\u3001\u30bb\u30eb\u30ed\u30fc\u30b9\u7e4a\u7dad\u306e\u80ba\u5185\u6b8b\u7559\u3068\u7570\u7269\u53cd\u5fdc\u3092\u793a\u5506\u3059\u308b\u75c5\u5909\u3092\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u672c\u75c7\u4f8b\u3067\u306f\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u80f8\u90e8CT\u3067\u7d30\u6c17\u7ba1\u652f\u5468\u56f2\u3092\u4e3b\u4f53\u3068\u3059\u308b\u3073\u307e\u3093\u6027\u9593\u8cea\u6027\u80a5\u539a<\/li>\n\n\n\n<li>\u80ba\u751f\u691c\u3067\u8089\u82bd\u816b\u5f62\u6210\u304a\u3088\u3073\u7dda\u7dad\u5316<\/li>\n\n\n\n<li>\u8d64\u5916\u5206\u5149\u5206\u6790\u306b\u3088\u308b\u5929\u7136\u30bb\u30eb\u30ed\u30fc\u30b9\u306e\u540c\u5b9a<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7279\u306b\u91cd\u8981\u306a\u306e\u306f\u3001\u5178\u578b\u7684\u306abyssinosis\u306e\u3088\u3046\u306a\u53ef\u9006\u6027\u6c17\u9053\u9589\u585e\u3067\u306f\u306a\u304f\u3001<strong>\u300c\u7e4a\u7dad\u6b8b\u7559\u306b\u4f34\u3046\u7570\u7269\u53cd\u5fdc\u300d<\/strong>\u3068\u3044\u3046\u75c5\u614b\u50cf\u3092\u793a\u3057\u305f\u70b9\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u307e\u305f\u3001\u4e3b\u3068\u3057\u3066\u4e2d\u67a2\u6c17\u9053\u306e\u9589\u585e\u6027\u969c\u5bb3\u3092\u53cd\u6620\u3059\u308b\u6307\u6a19\u3067\u3042\u308bFEV\u2081\u306e\u9855\u8457\u306a\u4f4e\u4e0b\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\u4e00\u65b9\u3001\u5c0f\u6c17\u9053\u6a5f\u80fd\u4f4e\u4e0b\u304c\u793a\u5506\u3055\u308c\u3066\u304a\u308a\u3001\u75c5\u5909\u306e\u4e3b\u5ea7\u304c\u672b\u68a2\u6c17\u9053\u9818\u57df\u306b\u5b58\u5728\u3057\u3066\u3044\u305f\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u305f\u3060\u3057\u3001\u672c\u77e5\u898b\u306f\u5358\u4e00\u75c7\u4f8b\u5831\u544a\u3067\u3042\u308a\u3001\u4e00\u822c\u5316\u306b\u306f\u614e\u91cd\u306a\u89e3\u91c8\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>2\uff09byssinosis\u306f\u4e3b\u3068\u3057\u3066\u6c17\u9053\u4e2d\u5fc3\u306e\u6709\u6a5f\u7c89\u3058\u3093\u708e\u75c7\u3067\u3042\u308a\u3001\u30a8\u30f3\u30c9\u30c8\u30ad\u30b7\u30f3\u306e\u95a2\u4e0e\u304c\u91cd\u8981\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">byssinosis\u306f\u3001\u7dbf\u306a\u3069\u306e\u690d\u7269\u7e4a\u7dad\u7c89\u3058\u3093\u3078\u306e\u6162\u6027\u66dd\u9732\u306b\u3088\u3063\u3066\u751f\u3058\u308b\u8077\u696d\u6027\u547c\u5438\u5668\u75be\u60a3\u3067\u3042\u308a\u3001\u4e3b\u3068\u3057\u3066\u30a8\u30f3\u30c9\u30c8\u30ad\u30b7\u30f3\u306b\u95a2\u9023\u3057\u305f\u53ef\u9006\u6027\u6c17\u9053\u708e\u75c7\u3068\u3057\u3066\u7406\u89e3\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u9031\u521d\u3081\u306b\u80f8\u90e8\u5727\u8feb\u611f\u3084\u547c\u5438\u56f0\u96e3\u304c\u60aa\u5316\u3059\u308b \u201cMonday chest tightness\uff08\u9031\u521d\u3081\u80f8\u90e8\u5727\u8feb\u611f\uff09\u201d \u304c\u53e4\u5178\u7684\u7279\u5fb4\u3068\u3057\u3066\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u75c5\u614b\u306e\u4e2d\u5fc3\u306f\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u6c17\u9053\u53ce\u7e2e<\/li>\n\n\n\n<li>\u9589\u585e\u6027\u63db\u6c17\u969c\u5bb3<\/li>\n\n\n\n<li>\u6162\u6027\u6c17\u9053\u708e\u75c7<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u3067\u3042\u308a\u3001\u8fd1\u5e74\u3067\u306f\u5598\u606f\u69d8\u53cd\u5fdc\u304b\u3089COPD\uff08\u6162\u6027\u9589\u585e\u6027\u80ba\u75be\u60a3\uff09\u69d8\u5909\u5316\u307e\u3067\u3092\u542b\u3080\u9023\u7d9a\u4f53\u3068\u3057\u3066\u6574\u7406\u3055\u308c\u3066\u3044\u307e\u3059\u3002COPD\u306f\u3001\u4e3b\u306b\u55ab\u7159\u3084\u7c89\u3058\u3093\u66dd\u9732\u306a\u3069\u306b\u3088\u308a\u751f\u3058\u308b\u6301\u7d9a\u7684\u304b\u3064\u9032\u884c\u6027\u306e\u6c17\u6d41\u5236\u9650\u3092\u7279\u5fb4\u3068\u3059\u308b\u75be\u60a3\u3067\u3042\u308a\u3001\u4e00\u90e8\u306f\u4e0d\u53ef\u9006\u7684\u306a\u9589\u585e\u6027\u969c\u5bb3\u3078\u3068\u9032\u5c55\u3057\u307e\u3059\u3002byssinosis\u3067\u306f\u3001\u75c5\u7406\u5b66\u7684\u306b\u306f\u6c17\u9053\u4e2d\u5fc3\u306e\u708e\u75c7\u304c\u4e3b\u4f53\u3067\u3042\u308a\u3001\u8089\u82bd\u816b\u5f62\u6210\u3084\u9855\u8457\u306a\u9593\u8cea\u7dda\u7dad\u5316\u306f\u5178\u578b\u7684\u6240\u898b\u3067\u306f\u3042\u308a\u307e\u305b\u3093\uff08<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3725301\/\" target=\"_blank\" rel=\"noopener\" title=\"\">Lai and Christiani, 2013<\/a>\uff09\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/doi.org\/10.1164\/ajrccm.163.4.2006063\" target=\"_blank\" rel=\"noopener\" title=\"\">Christiani et al. (2001)<\/a>\u306e15\u5e74\u9593\u8ffd\u8de1\u7814\u7a76\u3067\u306f\u3001\u7dbf\u5de5\u5834\u52b4\u50cd\u8005\u306b\u304a\u3044\u3066FEV\u2081\u304a\u3088\u3073FVC\uff08\u80ba\u306e\u63db\u6c17\u5bb9\u91cf\u3092\u53cd\u6620\u3059\u308b\u6307\u6a19\uff09\u306e\u7d4c\u5e74\u7684\u4f4e\u4e0b\u304c\u8a8d\u3081\u3089\u308c\u3066\u304a\u308a\u3001\u6162\u6027\u7684\u9589\u585e\u6027\u969c\u5bb3\u3078\u306e\u9032\u884c\u3082\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e00\u65b9\u3001Kobayashi\u75c7\u4f8b\u3067\u306f\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u8089\u82bd\u816b\u5f62\u6210<\/li>\n\n\n\n<li>\u9593\u8cea\u7dda\u7dad\u5316<\/li>\n\n\n\n<li>\u7e4a\u7dad\u6b8b\u7559<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u304c\u4e3b\u4f53\u3067\u3042\u308a\u3001\u5178\u578b\u7684\u306abyssinosis\u3068\u306f\u7570\u306a\u308b\u75c5\u614b\u8868\u73fe\u578b\u3068\u3057\u3066\u4f4d\u7f6e\u3065\u3051\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>3\uff09\u7e4a\u7dad\u66dd\u9732\u306b\u3088\u308b\u80ba\u969c\u5bb3\u306f\u300c\u6c17\u9053\u708e\u75c7\u300d\u3060\u3051\u3067\u306f\u306a\u3044<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/doi.org\/10.1378\/chest.108.5.1196\" target=\"_blank\" rel=\"noopener\" title=\"\">Lougheed et al. (1995)<\/a>\u306f\u3001\u7e4a\u7dad\u5de5\u5834\u52b4\u50cd\u8005\u306b\u304a\u3044\u3066\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>DIP\u69d8\u5909\u5316<\/li>\n\n\n\n<li>\u3073\u307e\u3093\u6027\u80ba\u80de\u969c\u5bb3\uff08DAD\uff09<\/li>\n\n\n\n<li>\u9593\u8cea\u6027\u80ba\u708e\u50cf<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u3092\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u3053\u3067\u3044\u3046DIP\u69d8\u5909\u5316\u3068\u306f\u3001\u80ba\u80de\u5185\u3078\u306e\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u96c6\u7a4d\u3092\u4e3b\u4f53\u3068\u3059\u308b\u53cd\u5fdc\u6027\u80ba\u969c\u5bb3\u3067\u3059\u3002\u3053\u308c\u3089\u306e\u75c7\u4f8b\u3067\u306f\u3001\u5358\u7d14\u306a\u53ef\u9006\u6027\u6c17\u9053\u9589\u585e\u3067\u306f\u306a\u304f\u3001\u80ba\u80de\u30fb\u9593\u8cea\u9818\u57df\u306e\u708e\u75c7\u304c\u4e3b\u4f53\u3067\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u75c7\u4f8b\u3067\u306f\u8907\u5408\u66dd\u9732\u306e\u5bc4\u4e0e\u304c\u793a\u5506\u3055\u308c\u3066\u304a\u308a\u3001\u30bb\u30eb\u30ed\u30fc\u30b9\u5358\u72ec\u5f71\u97ff\u3092\u76f4\u63a5\u793a\u3059\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u3057\u304b\u3057\u3001<strong>\u690d\u7269\u6027\u7e4a\u7dad\u95a2\u9023\u66dd\u9732\u306b\u3088\u308b\u80ba\u75c5\u5909\u304cbyssinosis\u3060\u3051\u306b\u9650\u5b9a\u3055\u308c\u306a\u3044\u53ef\u80fd\u6027<\/strong>\u3092\u793a\u3059\u70b9\u3067\u53c2\u8003\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4ee5\u4e0a\u3092\u8e0f\u307e\u3048\u308b\u3068\u3001<strong>\u30bb\u30eb\u30ed\u30fc\u30b9\u7e4a\u7dad\u66dd\u9732\u306b\u3088\u308b\u80ba\u969c\u5bb3\u306f\u3001byssinosis\u306b\u4ee3\u8868\u3055\u308c\u308b\u6c17\u9053\u4e2d\u5fc3\u306e\u9589\u585e\u6027\u969c\u5bb3\u306b\u52a0\u3048\u3001\u8907\u5408\u66dd\u9732\u306b\u3088\u308b\u9593\u8cea\u6027\u75c5\u5909\u3001\u3055\u3089\u306b\u306f\u7e4a\u7dad\u305d\u306e\u3082\u306e\u306e\u80ba\u5185\u6b8b\u7559\u306b\u95a2\u9023\u3059\u308b\u7570\u7269\u53cd\u5fdc\u307e\u3067\u3001\u591a\u69d8\u306a\u75c5\u614b\u30b9\u30da\u30af\u30c8\u30e9\u30e0\u3068\u3057\u3066\u6574\u7406\u3055\u308c\u307e\u3059<\/strong>\uff08\u88681\uff09\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u8868\uff11\u30bb\u30eb\u30ed\u30fc\u30b9\u7e4a\u7dad\u66dd\u9732\u306b\u3088\u308b\u80ba\u969c\u5bb3\u306e\u75c5\u614b\u30b9\u30da\u30af\u30c8\u30e9\u30e0\uff08\u6c17\u9053\u708e\u75c7\u304b\u3089\u9593\u8cea\u30fb\u7570\u7269\u53cd\u5fdc\u307e\u3067\uff09<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><td><strong>\u89b3\u70b9<\/strong><\/td><td><strong>Kobayashi<\/strong><strong>\uff082004\uff09<\/strong> <strong>\uff08\u7e4a\u7dad\u6b8b\u7559\u578b\u30e2\u30c7\u30eb\uff09<\/strong><\/td><td><strong>Lougheed et al.<\/strong><strong>\uff081995\uff09<\/strong> <strong>\uff08\u8907\u5408\u66dd\u9732\u30e2\u30c7\u30eb\uff09<\/strong><\/td><td><strong>Lai \/ Christiani<\/strong><strong>\uff082013\uff09<\/strong> <strong>\uff08\u6982\u5ff5\u30e2\u30c7\u30eb\uff09<\/strong><\/td><td><strong>Christiani et al.<\/strong><strong>\uff082001\uff09<\/strong> <strong>\uff08\u75ab\u5b66\u30e2\u30c7\u30eb\uff09<\/strong><\/td><\/tr><\/thead><tbody><tr><td><strong>\u5206\u985e<\/strong><\/td><td><strong>\u975ebyssinosis\uff08\u7e4a\u7dad\u6b8b\u7559\uff09<\/strong><\/td><td><strong>\u975ebyssinosis\uff08\u8907\u5408\u8981\u56e0\uff09<\/strong><\/td><td><strong>byssinosis<\/strong><strong>\u7cfb<\/strong><\/td><td><strong>byssinosis<\/strong><strong>\u7cfb<\/strong><\/td><\/tr><tr><td>\u4f4d\u7f6e\u3065\u3051<\/td><td>\u5358\u4e00\u75c7\u4f8b\u5831\u544a<\/td><td>\u75c7\u4f8b\u96c6\u7a4d\uff08\u8077\u696d\u6027\u9593\u8cea\u6027\u80ba\u75be\u60a3\uff09<\/td><td>\u7dcf\u8aac\uff08\u6982\u5ff5\u6574\u7406\uff09<\/td><td>\u9577\u671f\u75ab\u5b66\u7814\u7a76<\/td><\/tr><tr><td>\u4e3b\u75c5\u614b<\/td><td>\u9593\u8cea\uff0b\u672b\u68a2\u6c17\u9053\u75c5\u5909<\/td><td>\u9593\u8cea\u6027\u80ba\u708e\u30fb\u80ba\u80de\u969c\u5bb3<\/td><td>\u9589\u585e\u6027\u969c\u5bb3\uff08\u5598\u606f\u301cCOPD\uff09<\/td><td>\u9589\u585e\u6027\u969c\u5bb3\u306e\u9032\u884c<\/td><\/tr><tr><td>\u4e3b\u5ea7<\/td><td>\u672b\u68a2\u6c17\u9053\uff08\u7d30\u6c17\u7ba1\u652f\u5468\u56f2\uff09<\/td><td>\u80ba\u80de\u30fb\u9593\u8cea<\/td><td>\u4e2d\u67a2\u6c17\u9053<\/td><td>\u4e2d\u67a2\u6c17\u9053<\/td><\/tr><tr><td>\u6a5f\u5e8f<\/td><td>\u7e4a\u7dad\u6b8b\u7559\uff0b\u7570\u7269\u53cd\u5fdc<\/td><td>\u8907\u5408\u66dd\u9732\uff08\u4f8b\uff1a\u30de\u30a4\u30b3\u30c8\u30ad\u30b7\u30f3\uff09<\/td><td>\u30a8\u30f3\u30c9\u30c8\u30ad\u30b7\u30f3\u708e\u75c7<\/td><td>\u540c\u5de6<\/td><\/tr><tr><td>\u75c5\u7406<\/td><td>\u8089\u82bd\u816b\u30fb\u7dda\u7dad\u5316<\/td><td>DIP\u69d8\u5909\u5316\u3001\u3073\u307e\u3093\u6027\u80ba\u80de\u969c\u5bb3\uff08DAD\uff09<\/td><td>\u6c17\u9053\u708e\u75c7<\/td><td>\u540c\u5de6<\/td><\/tr><tr><td>\u53ef\u9006\u6027<\/td><td>\u4e0d\u660e\uff08\u6162\u6027\u5909\u5316\u3092\u793a\u5506\uff09<\/td><td>\u4e00\u90e8\u53ef\u9006\uff08\u66dd\u9732\u56de\u907f\u3067\u6539\u5584\u4f8b\u3042\u308a\uff09<\/td><td>\u53ef\u9006\u301c\u4e00\u90e8\u4e0d\u53ef\u9006<\/td><td>\u4e0d\u53ef\u9006\u9032\u884c\u3042\u308a<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>4\uff09\u30ca\u30ce\u30bb\u30eb\u30ed\u30fc\u30b9\u7814\u7a76\u3068\u306e\u3064\u306a\u304c\u308a<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8fd1\u5e74\u306e\u30ca\u30ce\u30bb\u30eb\u30ed\u30fc\u30b9\u5438\u5165\u6bd2\u6027\u7814\u7a76\u3067\u306f\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u8efd\u5ea6\u301c\u4e2d\u7b49\u5ea6\u306e\u708e\u75c7<\/li>\n\n\n\n<li>\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u96c6\u7a4d<\/li>\n\n\n\n<li>\u6761\u4ef6\u306b\u3088\u3063\u3066\u306f\u8089\u82bd\u816b\u69d8\u5909\u5316<\/li>\n\n\n\n<li>\u7de9\u5f90\u306a\u80ba\u30af\u30ea\u30a2\u30e9\u30f3\u30b9<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u306a\u3069\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7279\u306b\u91cd\u8981\u306a\u306e\u306f\u3001\u6bd2\u6027\u5f37\u5ea6\u305d\u306e\u3082\u306e\u3088\u308a\u3082\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u7e4a\u7dad\u5f84<\/li>\n\n\n\n<li>\u7e4a\u7dad\u9577<\/li>\n\n\n\n<li>\u51dd\u96c6\u72b6\u614b<\/li>\n\n\n\n<li>\u5206\u6563\u6027<\/li>\n\n\n\n<li>\u6b8b\u7559\u6027<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u3068\u3044\u3063\u305f\u7269\u7406\u7279\u6027\u304c\u3001\u751f\u4f53\u5fdc\u7b54\u3092\u5927\u304d\u304f\u5de6\u53f3\u3059\u308b\u70b9\u3067\u3059\u3002\u307e\u305f\u3001\u4e00\u90e8\u306e\u7814\u7a76\u3067\u306f\u3001\u6025\u6027\u708e\u75c7\u304c\u6bd4\u8f03\u7684\u8efd\u5fae\u3067\u3042\u3063\u3066\u3082\u3001\u6bd4\u8f03\u7684\u7de9\u5f90\u306a\u30af\u30ea\u30a2\u30e9\u30f3\u30b9\u3084\u6301\u7d9a\u53cd\u5fdc\u306e\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e00\u90e8\u306e\u52d5\u7269\u8a66\u9a13\u3067\u306f\u3001\u9650\u5c40\u6027\u306e\u8089\u82bd\u816b\u5f62\u6210\u3084\u7570\u7269\u53cd\u5fdc\u3082\u89b3\u5bdf\u3055\u308c\u3066\u3044\u307e\u3059(<a href=\"https:\/\/doi.org\/10.1016\/j.crtox.2025.100259\" target=\"_blank\" rel=\"noopener\" title=\"\">Fujita K, et al., 2025a<\/a>)\u3002\u3053\u308c\u3089\u306e\u77e5\u898b\u306f\u3001\u300c\u80ba\u5185\u6b8b\u7559\u3068\u6301\u7d9a\u53cd\u5fdc\u300d\u3068\u3044\u3046\u6982\u5ff5\u30ec\u30d9\u30eb\u3067\u306f\u3001Kobayashi\u75c7\u4f8b\u3068\u5171\u901a\u3059\u308b\u5074\u9762\u3092\u6709\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305f\u3060\u3057\u3001Kobayashi\u75c7\u4f8b\u3067\u8a8d\u3081\u3089\u308c\u305f\u3088\u3046\u306a\u3001\u9577\u671f\u7e4a\u7dad\u6b8b\u7559\u306b\u4f34\u3046\u6162\u6027\u7570\u7269\u53cd\u5fdc\u6027\u75c5\u5909\u3084\u7dda\u7dad\u5316\u6027\u80ba\u75c5\u5909\u3092\u3001\u30ca\u30ce\u30bb\u30eb\u30ed\u30fc\u30b9\u3067\u30d2\u30c8\u306b\u304a\u3044\u3066\u78ba\u8a8d\u3057\u305f\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u73fe\u6642\u70b9\u3067\u306f\u5b58\u5728\u3057\u3066\u3044\u307e\u305b\u3093\u3002\u307e\u305f\u3001\u75c5\u7406\u5b66\u7684\u8868\u73fe\u578b\u3001\u66dd\u9732\u671f\u9593\u3001\u66dd\u9732\u91cf\u3001\u306a\u3089\u3073\u306b\u6750\u6599\u7279\u6027\u306f\u3044\u305a\u308c\u3082\u5927\u304d\u304f\u7570\u306a\u308b\u305f\u3081\u3001\u4e21\u8005\u3092\u76f4\u63a5\u6bd4\u8f03\u3059\u308b\u969b\u306b\u306f\u614e\u91cd\u306a\u89e3\u91c8\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>5\uff09\u91cd\u8981\u306a\u306e\u306f\u300c\u5316\u5b66\u7d44\u6210\u300d\u3060\u3051\u3067\u306f\u306a\u304f\u300c\u5f62\u614b\u3068\u6b8b\u7559\u6027\u300d<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7e4a\u7dad\u6bd2\u6027\u5b66\u3067\u306f\u3001\u7e4a\u7dad\u5f84\u30fb\u7e4a\u7dad\u9577\u30fb\u525b\u76f4\u6027\u30fb\u6b8b\u7559\u6027\u304c\u3001\u751f\u4f53\u5f71\u97ff\u3092\u898f\u5b9a\u3059\u308b\u4e3b\u8981\u56e0\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30ca\u30ce\u30bb\u30eb\u30ed\u30fc\u30b9\u306b\u304a\u3044\u3066\u3082\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u9577\u7e4a\u7dad\u5316<\/li>\n\n\n\n<li>\u51dd\u96c6\u30fb\u675f\u5316<\/li>\n\n\n\n<li>\u5206\u6563\u4e0d\u826f<\/li>\n\n\n\n<li>\u80ba\u5185\u6b8b\u7559<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u306a\u3069\u304c\u3001\u708e\u75c7\u6301\u7d9a\u3084\u7570\u7269\u53cd\u5fdc\u306b\u95a2\u4e0e\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3057\u305f\u304c\u3063\u3066\u3001\u5b89\u5168\u6027\u8a55\u4fa1\u3067\u306f\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>mg\/m\u00b3\u306a\u3069\u306e\u8cea\u91cf\u6fc3\u5ea6<\/li>\n\n\n\n<li>\u7c92\u5b50\u5f84\u5206\u5e03\uff08\u7a7a\u6c17\u529b\u5b66\u5f84\uff09\u304a\u3088\u3073\u7e4a\u7dad\u5f84\u30fb\u7e4a\u7dad\u9577\u5206\u5e03<\/li>\n\n\n\n<li>\u7e4a\u7dad\u6570\u6fc3\u5ea6<\/li>\n\n\n\n<li>\u51dd\u96c6\u72b6\u614b<\/li>\n\n\n\n<li>\u80ba\u5185\u6b8b\u7559\u6027<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u3092\u7d71\u5408\u7684\u306b\u628a\u63e1\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>2. \u73fe\u5834\uff08\u4f5c\u696d\u74b0\u5883\uff09\u3078\u306e\u793a\u5506<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u300c\u4f4e\u6bd2\u6027\u6750\u6599\u300d\u3067\u3042\u3063\u3066\u3082\u5438\u5165\u8a2d\u8a08\u306f\u91cd\u8981<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30bb\u30eb\u30ed\u30fc\u30b9\u7cfb\u6750\u6599\u306f\u4e00\u822c\u306b\u4f4e\u6bd2\u6027\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u5438\u5165\u66dd\u9732\u3067\u306f\u300c\u7e4a\u7dad\u3068\u3057\u3066\u306e\u632f\u308b\u821e\u3044\u300d\u3092\u8003\u616e\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7279\u306b\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5fae\u7d30\u9577\u7e4a\u7dad\u306e\u767a\u751f<\/li>\n\n\n\n<li>\u51dd\u96c6\u30fb\u518d\u51dd\u96c6<\/li>\n\n\n\n<li>\u4e7e\u71e5\u5de5\u7a0b<\/li>\n\n\n\n<li>\u7c89\u4f53\u5316\u5de5\u7a0b<\/li>\n\n\n\n<li>\u9ad8\u30a8\u30cd\u30eb\u30ae\u30fc\u7834\u7815<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u306a\u3069\u3067\u306f\u3001\u5438\u5165\u6027\u7e4a\u7dad\u753b\u5206\u306e\u7ba1\u7406\u304c\u91cd\u8981\u3068\u306a\u308a\u307e\u3059\u3002\u8981\u3059\u308b\u306b\u3001\u30bb\u30eb\u30ed\u30fc\u30b9\u7cfb\u6750\u6599\u306e\u5438\u5165\u5b89\u5168\u6027\u3067\u306f\u3001<strong>\u300c\u7c89\u3058\u3093\u7ba1\u7406\u300d\u3060\u3051\u3067\u306a\u304f\u3001\u300c\u7e4a\u7dad\u3068\u3057\u3066\u306e\u66dd\u9732\u7ba1\u7406\u300d\u304c\u91cd\u8981<\/strong>\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u8a55\u4fa1\u306e\u7126\u70b9\u306f\u300c\u80ba\u5185\u6b8b\u7559\u3057\u5f97\u308b\u7e4a\u7dad\u753b\u5206\u300d<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7e4a\u7dad\u6bd2\u6027\u306e\u89b3\u70b9\u3067\u306f\u3001\u5358\u7d14\u306a\u8cea\u91cf\u6fc3\u5ea6\u3060\u3051\u3067\u306f\u4e0d\u5341\u5206\u3067\u3059\u3002\u7e4a\u7dad\u5f84\u3001\u7e4a\u7dad\u9577\u3001\u51dd\u96c6\u72b6\u614b\u3001\u5206\u6563\u6027\u3001\u30af\u30ea\u30a2\u30e9\u30f3\u30b9\u7279\u6027\u3092\u542b\u3081\u305f\u8a55\u4fa1\u304c\u3001\u4eca\u5f8c\u3055\u3089\u306b\u91cd\u8981\u306b\u306a\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>3. \u4eca\u5f8c\u306e\u8ab2\u984c<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u73fe\u6642\u70b9\u3067\u306f\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u30d2\u30c8\u9577\u671f\u66dd\u9732\u30c7\u30fc\u30bf<\/li>\n\n\n\n<li>\u5438\u5165\u66dd\u9732\u8a66\u9a13<\/li>\n\n\n\n<li>\u80ba\u5185\u52d5\u614b\u89e3\u6790<\/li>\n\n\n\n<li>\u7e4a\u7dad\u6570\u8a55\u4fa1\u6cd5<\/li>\n\n\n\n<li>\u5b9f\u4f5c\u696d\u74b0\u5883\u3067\u306e\u66dd\u9732\u8a55\u4fa1<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u306a\u3069\u306f\u5341\u5206\u306b\u84c4\u7a4d\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002\u4eca\u5f8c\u306f\u3001\u52d5\u7269\u5b9f\u9a13\u3068\u30d2\u30c8\u66dd\u9732\u77e5\u898b\u3092\u6a4b\u6e21\u3057\u3059\u308b\u7814\u7a76\u306e\u84c4\u7a4d\u304c\u91cd\u8981\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>4. \u7dcf\u62ec<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u672c\u7a3f\u3067\u6574\u7406\u3057\u305f\u77e5\u898b\u304b\u3089\u3001<strong>\u300c\u6709\u6a5f\u7c89\u3058\u3093\u3067\u3042\u3063\u3066\u3082\u3001\u66dd\u9732\u5f62\u614b\u3084\u7e4a\u7dad\u6b8b\u7559\u6027\u306b\u3088\u3063\u3066\u306f\u3001\u80ba\u5185\u6b8b\u7559\u306b\u95a2\u9023\u3057\u305f\u6162\u6027\u7684\u7570\u7269\u53cd\u5fdc\u3084\u7dda\u7dad\u5316\u75c5\u614b\u3092\u751f\u3058\u5f97\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u300d<\/strong>\u3068\u3044\u3046\u554f\u984c\u63d0\u8d77\u304c\u81ea\u7136\u306b\u5c0e\u304b\u308c\u307e\u3059\u3002\u305f\u3060\u3057\u3001\u73fe\u6642\u70b9\u3067\u306f\u3053\u306e\u8003\u3048\u65b9\u306f\u4eee\u8aac\u7684\u6bb5\u968e\u306b\u7559\u307e\u3063\u3066\u304a\u308a\u3001\u4e3b\u3068\u3057\u3066\u75c5\u614b\u5b66\u7684\u793a\u5506\u304a\u3088\u3073\u7e4a\u7dad\u6bd2\u6027\u5b66\uff08fiber toxicology\uff09\u306e\u89b3\u70b9\u304b\u3089\u691c\u8a0e\u3055\u308c\u308b\u3079\u304d\u8ad6\u70b9\u3068\u3057\u3066\u4f4d\u7f6e\u3065\u3051\u308b\u306e\u304c\u9069\u5207\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u3088\u3046\u306a\u89b3\u70b9\u304b\u3089\u898b\u308b\u3068\u3001Kobayashi\u3089\u306e\u75c7\u4f8b\u306f\u3001\u30bb\u30eb\u30ed\u30fc\u30b9\u66dd\u9732\u306b\u3088\u308b\u80ba\u5f71\u97ff\u3092\u3001\u5f93\u6765\u306ebyssinosis\u3060\u3051\u3067\u306f\u5341\u5206\u306b\u8aac\u660e\u3067\u304d\u306a\u3044\u53ef\u80fd\u6027\u3092\u793a\u3057\u305f\u91cd\u8981\u306a\u5831\u544a\u3067\u3059\u3002\u3055\u3089\u306b\u3001\u8fd1\u5e74\u306e\u30ca\u30ce\u30bb\u30eb\u30ed\u30fc\u30b9\u7814\u7a76\u306f\u3001\u30bb\u30eb\u30ed\u30fc\u30b9\u7cfb\u7e4a\u7dad\u306e\u5438\u5165\u5f71\u97ff\u304c\u3001\u5316\u5b66\u7d44\u6210\u3060\u3051\u3067\u306f\u306a\u304f\u3001\u300c\u7e4a\u7dad\u5f62\u614b\u300d\u300c\u51dd\u96c6\u72b6\u614b\u300d\u300c\u80ba\u5185\u6b8b\u7559\u6027\u300d\u3068\u3044\u3063\u305f\u7269\u7406\u7684\u8981\u56e0\u306b\u5f37\u304f\u4f9d\u5b58\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059(<a href=\"https:\/\/doi.org\/10.1016\/j.tox.2024.154038\" target=\"_blank\" rel=\"noopener\" title=\"\">Fujita K, et al., 2025b<\/a>; <a href=\"https:\/\/www.jstage.jst.go.jp\/browse\/kinoushi\/list\/-char\/ja\" target=\"_blank\" rel=\"noopener\" title=\"\">\u85e4\u7530\u514b\u82f1, 2025<\/a>)\u3002\u73fe\u6642\u70b9\u3067\u5f37\u3044\u6bd2\u6027\u3084\u767a\u304c\u3093\u6027\u3092\u76f4\u63a5\u793a\u3059\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u9650\u5b9a\u7684\u3067\u3059\u304c\u3001<strong>\u7e4a\u7dad\u6750\u6599\u3068\u3057\u3066\u306e\u7279\u6027\u3092\u8e0f\u307e\u3048\u305f\u5b89\u5168\u8a2d\u8a08\u3068\u66dd\u9732\u7ba1\u7406\u306f\u3001\u4eca\u5f8c\u3055\u3089\u306b\u9ad8\u307e\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u73fe\u5728\u3001\u30bb\u30eb\u30ed\u30fc\u30b9\u7c89\u3058\u3093\u3092\u6271\u3046\u4f5c\u696d\u74b0\u5883\u3067\u306f\u3001\u4e00\u822c\u7684\u306a\u7c89\u3058\u3093\u7ba1\u7406\u3084\u66dd\u9732\u4f4e\u6e1b\u5bfe\u7b56\u304c\u5b9f\u65bd\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u3053\u308c\u3089\u306f\u4e3b\u3068\u3057\u3066\u8cea\u91cf\u6fc3\u5ea6\u3092\u57fa\u76e4\u3068\u3057\u305f\u7ba1\u7406\u4f53\u7cfb\u3067\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u7e4a\u7dad\u9577\u3001\u51dd\u96c6\u72b6\u614b\u3001\u80ba\u5185\u6b8b\u7559\u6027\u3068\u3044\u3063\u305f\u7e4a\u7dad\u6bd2\u6027\u5b66\u7684\u89b3\u70b9\u306b\u3064\u3044\u3066\u306f\u3001\u6750\u6599\u7279\u6027\u306b\u5fdc\u3058\u305f\u8ffd\u52a0\u7684\u691c\u8a0e\u304c\u4eca\u5f8c\u306e\u8ab2\u984c\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uff08\u6587\u8cac\uff1a\u85e4\u7530\u514b\u82f1\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u672c\u7a3f\u306f\u3001\u516c\u958b\u6587\u732e\u306b\u57fa\u3065\u304d\u3001\u30ca\u30ce\u30bb\u30eb\u30ed\u30fc\u30b9\u5438\u5165\u6bd2\u6027\u306b\u95a2\u3059\u308b\u77e5\u898b\u3092\u6574\u7406\u3057\u305f\u3082\u306e\u3067\u3059\u3002\u7279\u5b9a\u306e\u75be\u60a3\u6982\u5ff5\u3001\u898f\u5236\u5224\u65ad\u3001\u5371\u967a\u6027\u5206\u985e\u3092\u793a\u3059\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u307e\u305f\u3001\u672c\u7a3f\u306e\u5185\u5bb9\u306f\u57f7\u7b46\u8005\u500b\u4eba\u306e\u898b\u89e3\u306b\u57fa\u3065\u304f\u3082\u306e\u3067\u3042\u308a\u3001\u57f7\u7b46\u8005\u304c\u6240\u5c5e\u307e\u305f\u306f\u95a2\u4fc2\u3059\u308b\u3044\u304b\u306a\u308b\u7d44\u7e54\u306e\u516c\u5f0f\u898b\u89e3\u3092\u793a\u3059\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u5f15\u7528\u6587\u732e<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Christiani DC, et al. Longitudinal changes in pulmonary function and respiratory symptoms in cotton textile workers: a 15-year follow-up study. Am J Respir Crit Care Med. 2001;163(4):847\u2013853.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Fujita K, Moriyama A. Inhalation toxicity of cellulose nanofibrils: a review of key findings and future directions. Carbohydr Polym Technol Appl. 2025;11:100913.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Fujita K, et al. Pulmonary inflammation and immune responses induced by nanocellulose: insights from <em>in vivo <\/em>and <em>in vitro <\/em>models. Curr Res Toxicol. 2025a;9:100259.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Fujita K, et al. Pulmonary inflammatory responses and retention dynamics of cellulose nanofibrils. Toxicology. 2025b;511:154038.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Horie M, et al. Evaluation of inflammatory and mesothelioma-related responses in mice following the intraperitoneal administration of cellulose nanofibers. NanoImpact. 2025;38:100561.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Kobayashi H, et al. Diffuse lung disease caused by cotton fibre inhalation but distinct from byssinosis. Thorax. 2004;59(12):1095\u20131097.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Lai PS, Christiani DC. Long-term respiratory health effects in textile workers. Curr Opin Pulm Med. 2013;19(2):152\u2013157.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Lougheed MD, et al. Desquamative interstitial pneumonitis and diffuse alveolar damage in textile workers: potential role of mycotoxins. Chest. 1995;108(5):1196\u20131200.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Ogura I, Kotake M. Dustiness and aerosol characteristics of nanocellulose powders: implications for workplace exposure and safety management. NanoImpact. 2025;38:100610.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u85e4\u7530\u514b\u82f1. \u6a5f\u80fd\u7d19\u7523\u696d\u306b\u304a\u3051\u308b\u30bb\u30eb\u30ed\u30fc\u30b9\u30ca\u30ce\u30d5\u30a1\u30a4\u30d0\u30fc\u306e\u30ea\u30b9\u30af\u3068\u53ef\u80fd\u6027\u2015\u5b89\u5168\u8a2d\u8a08\u3068\u6301\u7d9a\u53ef\u80fd\u306a\u5229\u7528\u306b\u5411\u3051\u305f\u8a55\u4fa1\u3068\u8ab2\u984c\u2015. \u6a5f\u80fd\u7d19\u7814\u7a76\u4f1a\u8a8c. 2025;64:23\u201330.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\uff082026\u5e745\u670820\u65e5\uff09 \u30bb\u30eb\u30ed\u30fc\u30b9\u304a\u3088\u3073\u30ca\u30ce\u30bb\u30eb\u30ed\u30fc\u30b9\u306f\u3001\u4e00\u822c\u306b\u751f\u4f53\u9069\u5408\u6027\u304c\u9ad8\u304f\u3001\u6bd4\u8f03\u7684\u5b89\u5168\u306a\u6750\u6599\u3068\u3057\u3066\u5e83\u304f\u8a8d\u8b58\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u98df\u54c1\u3001\u533b\u85ac\u3001\u5316\u7ca7\u54c1\u3001\u6a5f\u80fd\u6750\u6599\u306a\u3069\u591a\u69d8\u306a\u7528\u9014\u3067\u5229\u7528\u3055\u308c\u3066\u304a\u308a\u3001\u5316\u5b66\u7684\u306b\u3082\u5b89\u5b9a\u3067\u6bd2\u6027\u304c\u4f4e\u3044\u6750\u6599\u3068 [&hellip;]<\/p>\n","protected":false},"author":19,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[],"class_list":["post-2135","post","type-post","status-publish","format-standard","hentry","category-news"],"aioseo_notices":[],"acf":[],"_links":{"self":[{"href":"https:\/\/riss.aist.go.jp\/nanosafety\/wp-json\/wp\/v2\/posts\/2135","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/riss.aist.go.jp\/nanosafety\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/riss.aist.go.jp\/nanosafety\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/riss.aist.go.jp\/nanosafety\/wp-json\/wp\/v2\/users\/19"}],"replies":[{"embeddable":true,"href":"https:\/\/riss.aist.go.jp\/nanosafety\/wp-json\/wp\/v2\/comments?post=2135"}],"version-history":[{"count":13,"href":"https:\/\/riss.aist.go.jp\/nanosafety\/wp-json\/wp\/v2\/posts\/2135\/revisions"}],"predecessor-version":[{"id":2158,"href":"https:\/\/riss.aist.go.jp\/nanosafety\/wp-json\/wp\/v2\/posts\/2135\/revisions\/2158"}],"wp:attachment":[{"href":"https:\/\/riss.aist.go.jp\/nanosafety\/wp-json\/wp\/v2\/media?parent=2135"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/riss.aist.go.jp\/nanosafety\/wp-json\/wp\/v2\/categories?post=2135"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/riss.aist.go.jp\/nanosafety\/wp-json\/wp\/v2\/tags?post=2135"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}