Research
Activities and Results (June 2015)

Click the links in the Table of Contents below to jump to each R&D item’s results. You can download all the contents by clicking [here (PDF 2.97 MB)].
Please note that the project’s individual deliverables such as guidance notes, tentative standard protocols, methodological guides, to be uploaded in March 2016, should be downloaded separately and individually.

Table of Contents

Research and development item: ① “Development of methods for evaluating equivalence of nanomaterials”

①(a) Development of equivalence criteria based on comparison of nanomaterials by intratracheal administration testing results

Implemented by the Chemicals Evaluation and Research Institute

①(b) Sample preparation methods and characterization for equivalence evaluation

Implemented by the National Institute of Advanced Industrial Science and Technology

Research and development item ② “Development of low-cost, simple hazard assessment methods to acquire basic hazard information”

②(a) Comparative study of inhalation toxicity testing and intratracheal administration testing

Implemented by the University of Occupational and Environmental Health

②(b-1) Study on standardization of intratracheal administration testing: Study on standardization of the skill

Implemented by the Chemicals Evaluation and Research Institute

②(b-2) Study on standardization of intratracheal administration testing: Comparison of single and multiple administrations

Implemented by the Japan Bioassay Research Center

②(c) Development of a method for stable aerosol generation

Implemented by Hiroshima University

②(d) Development of a method of capturing aerosol particles in liquids

Implemented by the National Institute of Advanced Industrial Science and Technology

Research and development item ③ “Development of supporting methods for toxicity testing and assessment of nanomaterials”

③(a-1) Development of quantification methods for distributions of nanomaterials and biological responses

Implemented by the National Institute of Advanced Industrial Science and Technology

③(a-2) Development of measurement methods for toxicokinetics of PEAPOD

Implemented by Shinshu University

③(b) Development of mathematical models of toxicokinetics and biological responses of nanomaterials

Implemented by the National Institute of Advanced Industrial Science and Technology

③(c) Development of cell culture models of lung alveoli as evaluation systems for mathematical modeling

Implemented by the University of Tokyo

④ Monitoring international activities

Implemented by the National Institute of Advanced Industrial Science and Technology, and Keio University